Pamela Khacho
Pre-Clinical Science Coordinator
Laboratory and Operations Manager, University of Ottawa
NMD4C Involvement: Cell and Animal Based Research
Email PamelaBiography
Pamela Khacho is a neuroscientist and research operations leader with substantial experience in laboratory research, clinical trials, and regulatory affairs, and has supported teams across both academic and clinical research. She holds a PhD and Master’s in Neuroscience, as well as a Bachelor’s in Psychology with a minor in Biology from the University of Ottawa.
As the NMD4C Pre-Clinical Coordinator, Pamela supports the Animal and Cell-Based Research work package, including the annual summer school organizing committee, the research database, the annual award competitions, and the basic science training committee.
Pamela is also a Laboratory and Operations Manager at the University of Ottawa, where she supports research infrastructure and oversees lab operations. Previously, as a Regulatory Affairs Specialist, she ensured regulatory compliance across 25 Alzheimer’s disease clinical trials, and managed Health Canada and REB submissions and approvals.
Her research background includes investigating receptor mechanisms in brain health, and publishing in peer-reviewed journals.
Recent Publications
Cappelli, J, Khacho, P, Wang, B, Sokolovski, A, Bakkar, W, Raymond, S et al.. Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience. 2022.25 (1)103539 PMID:34977503
Khacho, P, Wang, B, Bergeron, R. The Good and Bad Sides of NAAG. Adv Pharmacol. 2016.76 311-49 PMID:27288081
Khacho, P, Wang, B, Ahlskog, N, Hristova, E, Bergeron, R. Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus. Neurobiol Dis. 2015.82 580-592 PMID:26303888
Khacho, M, Tarabay, M, Patten, D, Khacho, P, MacLaurin, JG, Guadagno, J et al.. Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nat Commun. 2014.5 3550 PMID:24686499
Bakkar, W, Ma, CL, Pabba, M, Khacho, P, Zhang, YL, Muller, E et al.. Chronically saturating levels of endogenous glycine disrupt glutamatergic neurotransmission and enhance synaptogenesis in the CA1 region of mouse hippocampus. Synapse. 2011.65 (11)1181-95 PMID:21633974
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