Élise Duchesne
Working Group Member
Associate Professor, Department of Health Sciences, Université du Québec à Chicoutimi
Researcher, Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN)
NMD4C Working Group(s): Biobanking
Email ÉliseResearch Interests: muscle plasticity, skeletal muscle physiology, macrophage, muscle biology / physiology, cell culture, innate immunity, flow cytometry, cellular immunology, muscle damage
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Biography
Dr. Duchesne graduated from Laval University’s physiotherapy program in 2006. Her passion for research led her to undertake a master’s degree followed by a Ph.D. from 2006 to 2012. Her thesis focused on skeletal muscle injuries, more specifically on the contribution of inflammation to the repair process. In January 2012, Dr. Duchesne was hired as a professor/researcher in the Université du Québec à Chicoutimi’s physiotherapy program.
As an independent researcher, her works focus namely on developing rehabilitation interventions. She carried out original and innovative experimental designs based on her knowledge in muscle physiology and her access to the large cohorts of NMD patients found in the Saguenay–Lac-St-Jean region such as myotonic dystrophy type I (DM1).
Her contributions to the field of neuromuscular diseases include the clinical and fundamental study of strength training effects on skeletal muscle impairments, the support of clinical trial readiness by reaching international consensus on outcome measures, the documentation of metrological properties, the documentation natural history of the disease and the establishment of a phenotypic data and biological material biobank.
Recent Publications
Nguyen, CDL, Jimenez-Moreno, AC, Merker, M, Bowers, CJ, Nikolenko, N, Hentschel, A et al.. Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1. J Neurol. 2023. PMID:36892629
Leduc-Gaudet, JP, Franco-Romero, A, Cefis, M, Moamer, A, Broering, FE, Milan, G et al.. MYTHO is a novel regulator of skeletal muscle autophagy and integrity. Nat Commun. 2023.14 (1)1199 PMID:36864049
Lessard, I, Masterman, V, Côté, I, Gagnon, C, Duchesne, E. A rehabilitation program to increase balance and mobility in ataxia of Charlevoix-Saguenay: An exploratory study. PLoS One. 2022.17 (12)e0279406 PMID:36576926
van Cruchten, RTP, van As, D, Glennon, JC, van Engelen, BGM, 't Hoen, PAC, OPTIMISTIC consortium et al.. Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood. BMC Med. 2022.20 (1)395 PMID:36352383
Bourcier, D, Bélair, N, Pedneault-Tremblay, ÉA, Lessard, I, Klockgether, T, Synofzik, M et al.. French Translation and Cross-cultural Adaptation of the Scale for the Assessment and Rating of Ataxia. Cerebellum. 2022. PMID:36208403
Gallais, B, Roussel, MP, Laberge, L, Hébert, LJ, Duchesne, E. Impact of a 12-week Strength Training Program on Fatigue, Daytime Sleepiness, and Apathy in Men with Myotonic Dystrophy Type 1. J Neuromuscul Dis. 2022.9 (5)629-639 PMID:35848033
Ravel-Chapuis, A, Duchesne, E, Jasmin, BJ. Pharmacological and exercise-induced activation of AMPK as emerging therapies for myotonic dystrophy type 1 patients. J Physiol. 2022.600 (14)3249-3264 PMID:35695045
Morin, M, Duchesne, E, Bernier, J, Blanchette, P, Langlois, D, Hébert, LJ et al.. What is Known About Muscle Strength Reference Values for Adults Measured by Hand-Held Dynamometry: A Scoping Review. Arch Rehabil Res Clin Transl. 2022.4 (1)100172 PMID:35282144
Bélair, N, Côté, I, Gagnon, C, Mathieu, J, Duchesne, E. Explanatory factors of dynamic balance impairment in myotonic dystrophy type 1. Muscle Nerve. 2022.65 (6)683-687 PMID:35212003
Roussel, MP, Fiset, MM, Gauthier, L, Lavoie, C, McNicoll, É, Pouliot, L et al.. Assessment of muscular strength and functional capacity in the juvenile and adult myotonic dystrophy type 1 population: a 3-year follow-up study. J Neurol. 2021.268 (11)4221-4237 PMID:33907889
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