Élise Duchesne

Elise Duchesne

Working Group Member

Associate Professor, Department of Health Sciences, Université du Québec à Chicoutimi

Researcher, Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN)


NMD4C Working Group(s): Biobanking

Email Élise

Research Interests: muscle plasticity, skeletal muscle physiology, macrophage, muscle biology / physiology, cell culture, innate immunity, flow cytometry, cellular immunology, muscle damage

Academic web profile
Google Scholar profile
ORCiD profile

Biography

Dr. Duchesne graduated from Laval University’s physiotherapy program in 2006. Her passion for research led her to undertake a master’s degree followed by a Ph.D. from 2006 to 2012. Her thesis focused on skeletal muscle injuries, more specifically on the contribution of inflammation to the repair process. In January 2012, Dr. Duchesne was hired as a professor/researcher in the Université du Québec à Chicoutimi’s physiotherapy program.

As an independent researcher, her works focus namely on developing rehabilitation interventions. She carried out original and innovative experimental designs based on her knowledge in muscle physiology and her access to the large cohorts of NMD patients found in the Saguenay–Lac-St-Jean region such as myotonic dystrophy type I (DM1).

Her contributions to the field of neuromuscular diseases include the clinical and fundamental study of strength training effects on skeletal muscle impairments, the support of clinical trial readiness by reaching international consensus on outcome measures, the documentation of metrological properties, the documentation natural history of the disease and the establishment of a phenotypic data and biological material biobank.


Recent Publications

Aoussim, A, Légaré, C, Roussel, MP, Madore, AM, Morissette, MC, Laprise, C et al.. Towards the Identification of Biomarkers for Muscle Function Improvement in Myotonic Dystrophy Type 1. J Neuromuscul Dis. 2023. PMID:37694373

Di Leo, V, Lawless, C, Roussel, MP, Gomes, TB, Gorman, GS, Russell, OM et al.. Resistance Exercise Training Rescues Mitochondrial Dysfunction in Skeletal Muscle of Patients with Myotonic Dystrophy Type 1. J Neuromuscul Dis. 2023. PMID:37638448

Conte, TC, Duran-Bishop, G, Orfi, Z, Mokhtari, I, Deprez, A, Côté, I et al.. Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1. Nat Commun. 2023.14 (1)4033 PMID:37468473

Davey, EE, Légaré, C, Planco, L, Shaughnessy, S, Lennon, CD, Roussel, MP et al.. Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1. JCI Insight. 2023.8 (14) PMID:37318869

Morin, M, Hébert, LJ, Perron, M, Petitclerc, É, Lake, SR, Duchesne, E et al.. Psychometric properties of a standardized protocol of muscle strength assessment by hand-held dynamometry in healthy adults: a reliability study. BMC Musculoskelet Disord. 2023.24 (1)294 PMID:37060020

Nguyen, CDL, Jimenez-Moreno, AC, Merker, M, Bowers, CJ, Nikolenko, N, Hentschel, A et al.. Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1. J Neurol. 2023.270 (6)3138-3158 PMID:36892629

Leduc-Gaudet, JP, Franco-Romero, A, Cefis, M, Moamer, A, Broering, FE, Milan, G et al.. MYTHO is a novel regulator of skeletal muscle autophagy and integrity. Nat Commun. 2023.14 (1)1199 PMID:36864049

Lessard, I, Masterman, V, Côté, I, Gagnon, C, Duchesne, E. A rehabilitation program to increase balance and mobility in ataxia of Charlevoix-Saguenay: An exploratory study. PLoS One. 2022.17 (12)e0279406 PMID:36576926

van Cruchten, RTP, van As, D, Glennon, JC, van Engelen, BGM, 't Hoen, PAC, OPTIMISTIC consortium et al.. Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood. BMC Med. 2022.20 (1)395 PMID:36352383

Bourcier, D, Bélair, N, Pedneault-Tremblay, ÉA, Lessard, I, Klockgether, T, Synofzik, M et al.. French Translation and Cross-cultural Adaptation of the Scale for the Assessment and Rating of Ataxia. Cerebellum. 2022. PMID:36208403

See more on PubMed