Fabio Rossi
Professor, University of British Columbia
NMD4C Involvement: Pillar 1: Preclinical Science
Email FabioBiography
Dr. Rossi’s research focuses on the biology and therapeutic applications of adult stem cells, and specifically on the role of inflammation in regeneration and on the role of stem cells in degenerative disease. After completing his medical education in Genoa, Italy, he obtained a Ph.D. in Thomas Graf’s laboratory at the European Molecular Biology Laboratories in Heidelberg, Germany were he first started working on bone marrow derived stem cells. During his postdoctoral work with Helen Blau at Stanford University he developed several novel tools and methods to study biological events (e.g. protein-protein interactions) at the single cell level. This work is at the basis of Discoverex’s highly successful series of GPCR reporter cell lines. He was the first to demonstrate that microglia can self renew within the CNS and provided the first description of the role of fibro/adipogenic progenitors in muscle regeneration and degeneration. His current research focus is on the crosstalk between innate immune cells, stromal stem/progenitors and tissue specific stem cells, how it regulates the response to damage in skeletal and cardiac muscle, and how these mechanism go awry and contribute to fibrotic degeneration in chronic disease. Dr Rossi has also been active in the community, founding and currently directing the BC Regenerative Medicine Initiative, focussed on fostering colaborative endeavours and knowledge translation among Regenerative Medicine Researchers throughout BC and the Cascadia region.
Recent Publications
Stankiewicz, LN, Rossi, FMV, Zandstra, PW. Rebuilding and rebooting immunity with stem cells. Cell Stem Cell. 2024. PMID:38593798
Younesi, FS, Miller, AE, Barker, TH, Rossi, FMV, Hinz, B. Fibroblast and myofibroblast activation in normal tissue repair and fibrosis. Nat Rev Mol Cell Biol. 2024. PMID:38589640
Day, KS, Rempel, L, Rossi, FMV, Theret, M. Origins and functions of eosinophils in two non-mucosal tissues. Front Immunol. 2024.15 1368142 PMID:38585275
Schutz, PW, Cheung, S, Yi, L, Rossi, FMV. Cellular activation patterns of CD10+ fibro-adipogenic progenitors across acquired disease states in human skeletal muscle biopsies. Free Neuropathol. 2024.5 PMID:38357523
Babaeijandaghi, F, Kajabadi, N, Long, R, Tung, LW, Cheung, CW, Ritso, M et al.. DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages. Nat Commun. 2023.14 (1)8273 PMID:38092736
Groppa, E, Tung, LW, Mattevi, S, Ritso, M, Rossi, FMV, Martini, P et al.. Protocol for generation of a time-resolved cellular interactome during tissue remodeling in adult mice. STAR Protoc. 2023.4 (4)102638 PMID:37831606
Kajabadi, N, Low, M, Jacques, E, Lad, H, Tung, LW, Babaeijandaghi, F et al.. Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss. Dev Cell. 2023.58 (6)489-505.e7 PMID:36898377
Groppa, E, Martini, P, Derakhshan, N, Theret, M, Ritso, M, Tung, LW et al.. Spatial compartmentalization of signaling imparts source-specific functions on secreted factors. Cell Rep. 2023.42 (2)112051 PMID:36729831
Babaeijandaghi, F, Paiero, A, Long, R, Tung, LW, Smith, SP, Cheng, R et al.. TNFα and IFNγ cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration. Proc Natl Acad Sci U S A. 2022.119 (44)e2209976119 PMID:36279473
Donen, GS, White, Z, Sauge, E, Ritso, M, Theret, M, Boyd, J et al.. Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy. Muscle Nerve. 2022.66 (4)513-522 PMID:35859452
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