The Neuromuscular Disease Network for Canada


Jason Karamchandani


Working Group Member

Associate Professor in the Department of Pathology, McGill University

Neuropathologist at The Montreal Neurological Institute and Hospital; McGill University Health Centre Research Institute

NMD4C Working Group(s): Biobanking

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Dr. Jason Karamchandani is an Associate Professor in the Department of Pathology and is a clinical neuropathologist at The Montreal Neurological Institute and Hospital where he supports adult and pediatric pathology, including neuromuscular pathology. His research employs bio-informatic data to identify and to characterize biomarkers relevant to classification and prognosis of brain tumours and neuromuscular disorders. His laboratory at the Neuro examines pathologies of both the central nervous system as well as neuromuscular disease.

A graduate of Harvard University, where he received his AB Honours degree in biochemistry cum laude, Dr. Karamchandani earned his medical degree at Stanford University School of Medicine where he was class valedictorian. At Stanford, he pursued residency training in anatomic pathology, as well as fellowship training in surgical pathology and neuropathology. He currently serves as the vice-president of the Canadian Association of Pathology.

Among his scientific achievements, Dr. Karamchandani has authored or co-authored over 60 publications in peer-reviewed journals. He has published four book chapters, with the most recent describing the molecular alterations and clinical tests in tumours of the central nervous system, and tumours of the spinal cord.

Recent Publications

Picher-Martel, V, Magnussen, C, Blais, M, Bubela, T, Das, S, Dionne, A et al.. CAPTURE ALS: the comprehensive analysis platform to understand, remedy and eliminate ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2022. 1-7 PMID:35195049

Roy, F, Korathanakhun, P, Karamchandani, J, Dubé, BP, Landon-Cardinal, O, Routhier, N et al.. Myositis with prominent B-cell aggregates causing shrinking lung syndrome in systemic lupus erythematosus: a case report. BMC Rheumatol. 2022.6 (1)11 PMID:35168668

Pichette, É, O'Ferrall, E, Karamchandani, J, Savarese, M, Udd, B, Massie, R et al.. Scapuloperoneal syndrome with mitochondrial DNA deletion. J Neurol Sci. 2022.434 120164 PMID:35121208

Mohamed, NV, Sirois, J, Ramamurthy, J, Mathur, M, Lépine, P, Deneault, E et al.. Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy. Brain Commun. 2021.3 (4)fcab223 PMID:34632384

Chen, CX, Abdian, N, Maussion, G, Thomas, RA, Demirova, I, Cai, E et al.. A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types. Methods Protoc. 2021.4 (3) PMID:34287353

Leclair, V, D'Aoust, J, Gyger, G, Landon-Cardinal, O, Meyer, A, O'Ferrall, E et al.. Autoantibody profiles delineate distinct subsets of scleromyositis. Rheumatology (Oxford). 2022.61 (3)1148-1157 PMID:34146090

Das, S, Abou-Haidar, R, Rabalais, H, Sun, SDLW, Rosli, Z, Chatpar, K et al.. The C-BIG Repository: an Institution-Level Open Science Platform. Neuroinformatics. 2021. PMID:34003431

Pathak, R, Zin, F, Thomas, C, Bens, S, Gayden, T, Karamchandani, J et al.. Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors. Acta Neuropathol. 2021.142 (2)361-374 PMID:34003336

Chen, CCL, Deshmukh, S, Jessa, S, Hadjadj, D, Lisi, V, Andrade, AF et al.. Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell. 2020.183 (6)1617-1633.e22 PMID:33259802

Khazaei, S, De Jay, N, Deshmukh, S, Hendrikse, LD, Jawhar, W, Chen, CCL et al.. H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone. Cancer Discov. 2020.10 (12)1968-1987 PMID:32967858

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