Jason Karamchandani


Working Group Member

Associate Professor in the Department of Pathology, McGill University

Neuropathologist at The Montreal Neurological Institute and Hospital; McGill University Health Centre Research Institute

NMD4C Working Group(s): Biobanking

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Dr. Jason Karamchandani is an Associate Professor in the Department of Pathology and is a clinical neuropathologist at The Montreal Neurological Institute and Hospital where he supports adult and pediatric pathology, including neuromuscular pathology. His research employs bio-informatic data to identify and to characterize biomarkers relevant to classification and prognosis of brain tumours and neuromuscular disorders. His laboratory at the Neuro examines pathologies of both the central nervous system as well as neuromuscular disease.

A graduate of Harvard University, where he received his AB Honours degree in biochemistry cum laude, Dr. Karamchandani earned his medical degree at Stanford University School of Medicine where he was class valedictorian. At Stanford, he pursued residency training in anatomic pathology, as well as fellowship training in surgical pathology and neuropathology. He currently serves as the vice-president of the Canadian Association of Pathology.

Among his scientific achievements, Dr. Karamchandani has authored or co-authored over 60 publications in peer-reviewed journals. He has published four book chapters, with the most recent describing the molecular alterations and clinical tests in tumours of the central nervous system, and tumours of the spinal cord.

Recent Publications

X-Q Chen, C, Deneault, E, Abdian, N, You, Z, Sirois, J, Nicouleau, M et al.. Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson's associated GBA gene. Stem Cell Res. 2022.64 102919 PMID:36130446

Ellezam, B, Leclair, V, Troyanov, Y, Bersali, I, Giannini, M, Hoa, S et al.. Capillary pathology with prominent basement membrane reduplication is the hallmark histopathological feature of scleromyositis. Neuropathol Appl Neurobiol. 2022. e12840 PMID:35894636

Salmon, K, Ross, JP, Bertone, V, Gobbo, M, Anoja, N, Karamchandani, J et al.. The value of testing for ATXN2 intermediate repeat expansions in routine clinical practice for amyotrophic lateral sclerosis. Eur J Hum Genet. 2022. PMID:35864146

Daniel, P, Meehan, B, Sabri, S, Jamali, F, Sarkaria, JN, Choi, D et al.. Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma. Neurooncol Adv. .4 (1)vdac076 PMID:35795471

Mezreani, J, Audet, S, Martin, F, Charbonneau, J, Triassi, V, Bareke, E et al.. Novel homozygous nonsense mutation of MLIP and compensatory alternative splicing. NPJ Genom Med. 2022.7 (1)36 PMID:35672413

Chen, CX, You, Z, Abdian, N, Sirois, J, Shlaifer, I, Tabatabaei, M et al.. Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing. Stem Cell Res. 2022.62 102806 PMID:35561458

Picher-Martel, V, Magnussen, C, Blais, M, Bubela, T, Das, S, Dionne, A et al.. CAPTURE ALS: the comprehensive analysis platform to understand, remedy and eliminate ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2022. 1-7 PMID:35195049

Roy, F, Korathanakhun, P, Karamchandani, J, Dubé, BP, Landon-Cardinal, O, Routhier, N et al.. Myositis with prominent B-cell aggregates causing shrinking lung syndrome in systemic lupus erythematosus: a case report. BMC Rheumatol. 2022.6 (1)11 PMID:35168668

Pichette, É, O'Ferrall, E, Karamchandani, J, Savarese, M, Udd, B, Massie, R et al.. Scapuloperoneal syndrome with mitochondrial DNA deletion. J Neurol Sci. 2022.434 120164 PMID:35121208

Mohamed, NV, Sirois, J, Ramamurthy, J, Mathur, M, Lépine, P, Deneault, E et al.. Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy. Brain Commun. 2021.3 (4)fcab223 PMID:34632384

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