Jason Karamchandani

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Working Group Member

Associate Professor, Department of Pathology, McGill University

Clinical Neuropathologist, Scientific Director of C-BIG Repository, The Montreal Neurological Institute and Hospital, McGill University Health Centre Research Institute


NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science

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Biography

Dr. Jason Karamchandani is an Associate Professor in the Departments of Pathology, Neurology & Neuroscience and is a clinical neuropathologist at The Montreal Neurological Institute and Hospital (the Neuro) where he supports adult and pediatric pathology, including neuromuscular pathology. He serves as the Scientific Director of the Neuro’s Open Science biobank and patient registry, C-BIG. 

A graduate of Harvard University, where he received his AB Honours degree in biochemistry cum laude, Dr. Karamchandani earned his medical degree at Stanford University School of Medicine where he was class valedictorian. At Stanford, he pursued residency training in anatomic pathology, as well as fellowship training in surgical pathology and neuropathology. He currently serves as the president of the Canadian Association of Pathology. 

Among his scientific achievements, Dr. Karamchandani has authored or co-authored over 80 publications in peer-reviewed journals. He has published four book chapters, with the most recent describing the molecular alterations and clinical tests in tumours of the central nervous system, and tumours of the spinal cord. 


Recent Publications

Shahzad, U, Nikolopoulos, M, Li, C, Johnston, M, Wang, JJ, Sabha, N et al.. CASCADES, a novel SOX2 super-enhancer-associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma. Mol Oncol. 2024. PMID:39323013

Wiesman, AI, Madge, V, Fon, EA, Dagher, A, Collins, DL, Baillet, S et al.. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. Brain. 2024. PMID:39282945

Andrade, AF, Annett, A, Karimi, E, Topouza, DG, Rezanejad, M, Liu, Y et al.. Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function. Nat Commun. 2024.15 (1)7769 PMID:39237515

Wang, P, Li, Z, Kim, SH, Xu, H, Huang, H, Yang, C et al.. PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation. Life Sci Alliance. 2024.7 (10) PMID:39111820

da Silva Castanheira, J, Wiesman, AI, Hansen, JY, Misic, B, Baillet, S, PREVENT-AD Research Group et al.. The neurophysiological brain-fingerprint of Parkinson's disease. EBioMedicine. 2024.105 105201 PMID:38908100

Bernier, A, Knoppers, BM, Bermudez, P, Beauvais, MJS, Thorogood, A, CONP Consortium et al.. Open Data governance at the Canadian Open Neuroscience Platform (CONP): From the Walled Garden to the Arboretum. Gigascience. 2024.13 PMID:38217404

Andriamboavonjy, L, MacDonald, A, Hamilton, LK, Labrecque, M, Boivin, MN, Karamchandani, J et al.. Comparative analysis of methods to reduce activation signature gene expression in PBMCs. Sci Rep. 2023.13 (1)23086 PMID:38155174

Krochmalnek, E, Accogli, A, St-Onge, J, Addour-Boudrahem, N, Prakash, G, Kim, SH et al.. mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development: Novel Variants, Topographic Mapping, and Clinical Outcomes. Neurol Genet. 2023.9 (6)e200103 PMID:37900581

Han, H, Renzi, S, Larouche, V, Faury, D, Langlois, S, Sinnett, D et al.. Germline Platelet-derived growth factor receptor beta p.R987W pathogenic variant in 2 children with brain tumors. Neurooncol Adv. 2023.5 (1)vdad029 PMID:37114246

Meyer, A, Troyanov, Y, Korathanakhun, P, Landon-Cardinal, O, Leclair, V, Allard-Chamard, H et al.. Myositis with prominent B cell aggregates may meet classification criteria for sporadic inclusion body myositis. Neuromuscul Disord. 2023.33 (2)169-182 PMID:36649672

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