The Neuromuscular Disease Network for Canada

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Kessen Patten

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NMD4C Working Group Member

Associate Professor - Centre Armand-Frappier Santé Biotechnologie

Institut National de la Recherche Scientifique (INRS)


NMD4C Working Group(s): Knowledge Translation

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Biography

Dr. Kessen Patten is an Associate Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.

 

The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases for new genetic identification and drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.

Recent publications

Rabanel, JM, Faivre, J, Zaouter, C, Patten, SA, Banquy, X, Ramassamy, C et al.. Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in zebrafish. Biomaterials. 2021.277 121085 PMID:34461457

Butti, Z, Pan, YE, Giacomotto, J, Patten, SA. Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish. Commun Biol. 2021.4 (1)792 PMID:34172817

Mathieu, H, Patten, SA, Aragon-Martin, JA, Ocaka, L, Simpson, M, Child, A et al.. Genetic variant of TTLL11 gene and subsequent ciliary defects are associated with idiopathic scoliosis in a 5-generation UK family. Sci Rep. 2021.11 (1)11026 PMID:34040021

Jamadagni, P, Breuer, M, Schmeisser, K, Cardinal, T, Kassa, B, Parker, JA et al.. Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression. EMBO Rep. 2021.22 (6)e50958 PMID:33900016

Doyle, JJ, Vrancx, C, Maios, C, Labarre, A, Patten, SA, Parker, JA et al.. Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy. Dis Model Mech. 2020.13 (12) PMID:33106327

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