Working Group Member
Professor - Centre Armand-Frappier Santé Biotechnologie
Institut National de la Recherche Scientifique (INRS)
NMD4C Working Group(s): Pillar 1: Preclinical Science, Theme 5: Open ScienceEmail Kessen
Dr. Kessen Patten is an Associate Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.
The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases (ALS and SMA) to understand disease mechanisms and for drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.
Silva, MJSA, Zhang, Y, Vinck, R, Santos, FMF, António, JPM, Gourdon-Grünewaldt, L et al.. BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation. Bioconjug Chem. 2023. PMID:37948301
Hassan, A, Bagu, ET, Patten, SA, Molidperee, S, Parent, S, Barchi, S et al.. Differential Regulation of POC5 by ERα in Human Normal and Scoliotic Cells. Genes (Basel). 2023.14 (5) PMID:37239471
Singh, J, Patten, SA. Modeling neuromuscular diseases in zebrafish. Front Mol Neurosci. 2022.15 1054573 PMID:36583079
Rabanel, JM, Mirbagheri, M, Olszewski, M, Xie, G, Le Goas, M, Latreille, PL et al.. Deep Tissue Penetration of Bottle-Brush Polymers via Cell Capture Evasion and Fast Diffusion. ACS Nano. 2022.16 (12)21583-21599 PMID:36516979
Latreille, PL, Rabanel, JM, Le Goas, M, Salimi, S, Arlt, J, Patten, SA et al.. In Situ Characterization of the Protein Corona of Nanoparticles In Vitro and In Vivo. Adv Mater. 2022.34 (38)e2203354 PMID:35901787See more on PubMed