Kessen Patten
Working Group Member
Associate Professor - Centre Armand-Frappier Santé Biotechnologie
Institut National de la Recherche Scientifique (INRS)
NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science
Email KessenBiography
Dr. Kessen Patten is an Associate Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.
The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases (ALS and SMA) to understand disease mechanisms and for drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.
Recent Publications
McDermott, A, Juarez, MN, Parra, DT, Duval, C, Patten, SA, Plante, I et al.. Gap junction communication regulates luminal-myoepithelial crosstalk and cell differentiation in a bilayered human mammary epithelial cell model. Biol Methods Protoc. 2026.11 (1)bpag031 PMID:42369194
Li, J, Haj-Husein, I, Ghafari, N, Khorraminezhad, L, Iskandar, M, Zaouter, C et al.. Untargeted metabolomics and proteomics reveals cocoa-mediated mitigation of valproic acid-induced dysregulation in a zebrafish model of autism: pilot study. Metabolomics. 2026.22 (4) PMID:42315748
Rein, DB, Peterson, C, Brault, MW, Lamuda, PA, Hackney, ME, Vaughan, CP et al.. The cost-effectiveness of the stopping elderly accidents, deaths and injuries options randomised quality improvement trial to prevent falls among older adults. Age Ageing. 2026.55 (6) PMID:42315165
Breuer, M, Fortier, G, Singh, J, Charron, S, Kassa, B, Jamadagni, P et al.. Chd7 regulates lipid metabolism and swim bladder inflation in zebrafish. J Lipid Res. 2026.67 (6)101062 PMID:42155613
Mencacci, NE, Minakaki, G, Maroofian, R, De Pace, R, Paimboeuf, A, Branco Fonseca, T et al.. Pathogenic variants in BORCS5 cause a spectrum of neurodevelopmental and neurodegenerative disorders with lysosomal dysfunction. J Clin Invest. 2026.136 (11) PMID:42012897
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