Kessen Patten
Working Group Member
Professor - Centre Armand-Frappier Santé Biotechnologie
Institut National de la Recherche Scientifique (INRS)
NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science
Email KessenBiography
Dr. Kessen Patten is an Associate Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.
The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases (ALS and SMA) to understand disease mechanisms and for drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.
Recent Publications
Breuer, M, Rummler, M, Singh, J, Maher, S, Zaouter, C, Jamadagni, P et al.. CHD7 regulates craniofacial cartilage development via controlling HTR2B expression. J Bone Miner Res. 2024. PMID:38477756
Oliveira Silva, R, Counil, H, Rabanel, JM, Haddad, M, Zaouter, C, Ben Khedher, MR et al.. Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles. Int J Nanomedicine. 2024.19 1077-1096 PMID:38317848
De Pace, R, Maroofian, R, Paimboeuf, A, Zamani, M, Zaki, MS, Sadeghian, S et al.. Biallelic BORCS8 variants cause an infantile-onset neurodegenerative disorder with altered lysosome dynamics. Brain. 2023. PMID:38128568
Singh, J, Pan, YE, Patten, SA. NMJ Analyser: a novel method to quantify neuromuscular junction morphology in zebrafish. Bioinformatics. 2023.39 (12) PMID:38058204
Silva, MJSA, Zhang, Y, Vinck, R, Santos, FMF, António, JPM, Gourdon-Grünewaldt, L et al.. BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation. Bioconjug Chem. 2023.34 (12)2337-2344 PMID:37948301
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