Martine Tetreault

Martine tetreault

Assistant Professor, Department of Neuroscience at Université de Montreal

Researcher, CRCHUM


NMD4C Involvement: Pillar 1: Preclinical Science

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Research Interests: myopathies, muscular dystrophies, genetics, omics, heterogeneity

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Biography

Dr. Tetreault is an Assistant professor in the department of Neuroscience at Université de Montreal and a researcher at the CRCHUM since January 2018.  She completed her graduate studies in Molecular Biology at Université de Montreal under the supervision of Dr Bernard Brais (CIHR bursary). Her research was focusing on genetic characterization of neurological diseases in the French-Canadian population.

Martine has then pursued her training as a post-doctoral fellow in the Human Genetic program at McGill University under the supervision of Dr Jacek Majewski (CIHR fellowship), where she has broadened her expertise of genetic studies by developing bio-informatics skills. Martine was performing the exome and whole genome sequencing analysis as part of the Care for Rare consortium led by Dr Kym Boycott in Ottawa. During this time, she has also put in place collaborations with neurologists and pathologists in order to use RNA-sequencing to find genetic causes of unresolved myopathy patients.

As an independent researcher, Dr. Tetreault is aiming at combining multiple omic approaches to study the genetic etiology of neuromuscular and neurodegenerative diseases. As a young investigator, Dr. Tetreault has been very productive with more than 50 publication, some of which in high impact journals such as Nature, Brain and American Journal of Human Genetics.

She has received funding from the Fondation Courtois, National Ataxia Foundation, Fondation du Grand Defi Pierre Lavoie, Muscular Dystrophy Canada and recently a Canadian Foundation for Innovation grant to establish a translational platform to study rare neuromuscular diseases.  She has also received a FRQS Junior 1 salary award.

Read Dr. Tetreault’s blog here!


Recent Publications

Deshaies, JE, Triassi, V, Lacombe, A, Gagné, M, Ling, K, Ghosh, A et al.. The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response. Sci Rep. 2025.15 (1)15306 PMID:40312500

Labrecque, M, Brunet-Ratnasingham, E, Hamilton, LK, Auld, D, Montpetit, A, Richards, B et al.. Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation. Sci Rep. 2025.15 (1)13469 PMID:40251257

Parisien-La Salle, S, Perreault, F, Corbeil, G, Morisset, J, Poirier, C, Beauregard, C et al.. Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient. Front Endocrinol (Lausanne). 2024.15 1481906 PMID:39981138

Manceau, R, Majeur, D, Cherian, CM, Miller, CJ, Wat, LW, Fisher, JD et al.. Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis. bioRxiv. 2024. PMID:39345476

Karuppasamy, M, Tetreault, M, Rosati, J. Editorial: Diagnosis, animal models and therapeutic interventions for neuromuscular diseases. Front Genet. 2024.15 1481705 PMID:39323868

Laflamme, N, Triassi, V, Martineau, L, Toffa, DH, Létourneau-Guillon, L, Laplante, A et al.. X-Linked Bilateral Polymicrogyria With Epilepsy and Intellectual Disability Associated With a Novel KIF4A Variant. Am J Med Genet A. 2025.197 (1)e63860 PMID:39268972

Brunet-Ratnasingham, E, Morin, S, Randolph, HE, Labrecque, M, Bélair, J, Lima-Barbosa, R et al.. Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024.15 (1)4177 PMID:38755196

Audet, S, Triassi, V, Gelinas, M, Legault-Cadieux, N, Ferraro, V, Duquette, A et al.. Integration of multi-omics technologies for molecular diagnosis in ataxia patients. Front Genet. 2023.14 1304711 PMID:38239855

Andriamboavonjy, L, MacDonald, A, Hamilton, LK, Labrecque, M, Boivin, MN, Karamchandani, J et al.. Comparative analysis of methods to reduce activation signature gene expression in PBMCs. Sci Rep. 2023.13 (1)23086 PMID:38155174

Hamilton, LK, Moquin-Beaudry, G, Mangahas, CL, Pratesi, F, Aubin, M, Aumont, A et al.. Author Correction: Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model. Nat Commun. 2023.14 (1)2674 PMID:37160868

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