Natasha Chang

Dr. Natasha Chang

Preclinical Science Co-Lead & Steering Committee Member

Associate Professor, Department of Biochemistry, McGill University

Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar


NMD4C Involvement: Pillar 1: Preclinical Science, Theme 1: Early-Career, Theme 5: Open Science

Email Natasha

Research Interests: Muscle stem cells, Muscle regeneration, Myogenesis, Duchenne muscular dystrophy

Academic web profile
Google Scholar profile
LinkedIn profile
ResearchGate profile
ORCiD profile
Twitter profile
Lab website

Biography

Dr. Natasha Chang is an Associate Professor at McGill University and a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar.

Dr. Chang’s research program investigates the molecular mechanisms that regulate muscle stem cell function in health and neuromuscular disease. Her laboratory combines fundamental stem cell biology with translational approaches to identify pathways that can be targeted to enhance muscle regeneration and treat degenerative muscle disorders, including Duchenne muscular dystrophy. Dr. Chang is also committed to training and mentoring the next generation of scientists through collaborative and interdisciplinary research programs and national training initiatives.

She represents basic science as a member of the NMD4C Steering Committee and is a Pillar 1: Preclinical Science Co-Lead.

Read Dr. Chang’s Early Career Blog here!


Recent Publications

Granet, JA, Robertson, R, Cusmano, AA, Filippelli, RL, Lorenz, TO, Li, S et al.. Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity. Cell Death Dis. 2025.16 (1)437 PMID:40473604

Cusmano, AA, VanGenderen, CA, Lorenz, TO, Yang, Y, Chang, NC. Efficient Isolation and Ex Vivo Differentiation of Murine Satellite Cells from Healthy and Dystrophic Muscle. Methods Mol Biol. 2025.2939 37-54 PMID:40117021

Liu, Y, Li, S, Robertson, R, Granet, JA, Aubry, I, Filippelli, RL et al.. PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophy. Life Sci Alliance. 2025.8 (1) PMID:39477543

Robertson, R, Li, S, Filippelli, RL, Chang, NC. Muscle stem cell dysfunction in rhabdomyosarcoma and muscular dystrophy. Curr Top Dev Biol. 2024.158 83-121 PMID:38670717

VanGenderen, CA, Granet, JA, Filippelli, RL, Liu, Y, Chang, NC. Modulating Myogenesis: An Optimized In Vitro Assay to Pharmacologically Influence Primary Myoblast Differentiation. Curr Protoc. 2022.2 (9)e565 PMID:36165685

Filippelli, RL, Kamyabiazar, S, Chang, NC. Monitoring Autophagy in Neural Stem and Progenitor Cells. Methods Mol Biol. 2022.2515 99-116 PMID:35776348

Filippelli, RL, Omer, A, Li, S, van Oostende-Triplet, C, Gallouzi, IE, Chang, NC et al.. Automated Quantification of Subcellular Particles in Myogenic Progenitors. Curr Protoc. 2021.1 (12)e325 PMID:34879178

Filippelli, RL, Chang, NC. Empowering Muscle Stem Cells for the Treatment of Duchenne Muscular Dystrophy. Cells Tissues Organs. 2022.211 (6)641-654 PMID:33910206

Chang, NC. Autophagy and Stem Cells: Self-Eating for Self-Renewal. Front Cell Dev Biol. 2020.8 138 PMID:32195258

Chang, NC, Sincennes, MC, Chevalier, FP, Brun, CE, Lacaria, M, Segalés, J et al.. The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment. Cell Stem Cell. 2018.22 (5)755-768.e6 PMID:29681515

See more on PubMed