Nicolas Dumont

Dr. Nicolas Dumont profile picture.

Associate professor, Rehabilitation department, University of Montreal

Principal Investigator, Musculoskeletal health research axis, Sainte-Justine Hospital research center


NMD4C Working Group(s): Pillar 1: Preclinical Science

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Biography

Dr. Nicolas Dumont obtained his PhD at the Université Laval where he studied the regulatory network between inflammatory cells and skeletal muscles. He did his post-doctoral training at the Ottawa Hospital Research Institute in Dr. Michael Rudnicki’s lab, where he studied muscle stem cell defects in Duchenne Muscular Dystrophy. Dr. Dumont became an assistant professor at the Université de Montréal in 2016, and he established his lab at the Sainte-Justine hospital research center. His research program is divided in 3 axes: 1) characterizing the intrinsic mechanisms regulating muscle stem cell fate decision during myogenesis, 2) characterizing the impact of rare genetic variants on muscle stem cell function, and 3) investigating novel therapeutic avenues targeting defective muscle stem cells to mitigate muscular dystrophies. Dr. Dumont holds a FRQS Junior-2 award, and his lab is funded by grants from the CIHR, NSERC, ThéCell network, Stem Cell Network, Orphan disease center, AFM-Telethon, and Muscular Dystrophy Canada.


Recent Publications

  1. Dort, J, Orfi, Z, Fiscaletti, M, Campeau, PM, Dumont, NA. Gpr18 agonist dampens inflammation, enhances myogenesis, and restores muscle function in models of Duchenne muscular dystrophy. Front Cell Dev Biol. 2023.11 1187253 PMID:37645248
  2. Marmen, MB, Orfi, Z, Dort, J, Proulx-Gauthier, JP, Chrestian, N, Dumont, NA et al.. Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy. Acta Neuropathol. 2023.146 (4)655-658 PMID:37543531
  3. Conte, TC, Duran-Bishop, G, Orfi, Z, Mokhtari, I, Deprez, A, Côté, I et al.. Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1. Nat Commun. 2023.14 (1)4033 PMID:37468473
  4. Da Silva, A, Dort, J, Orfi, Z, Pan, X, Huang, S, Kho, I et al.. N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function. Sci Adv. 2023.9 (26)eade6308 PMID:37390204
  5. Dominici, C, Villarreal, OD, Dort, J, Heckel, E, Wang, YC, Ragoussis, I et al.. Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity. Elife. 2023.12 PMID:37285284
  6. Deprez, A, Orfi, Z, Rieger, L, Dumont, NA. Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies. Biosci Rep. 2023.43 (1) PMID:36538023
  7. Sénéchal, C, Fujita, R, Jamet, S, Maiga, A, Dort, J, Orfi, Z et al.. The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool. Cell Rep. 2022.41 (7)111645 PMID:36384129
  8. Raad, S, David, A, Sagniez, M, Paré, B, Orfi, Z, Dumont, NA et al.. iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage. Dis Model Mech. 2022.15 (11) PMID:36317486
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