Nicolas Dumont

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Université de Montréal, Faculty of Medicine, Department of Rehabilitation

CHU Sainte-Justine research center


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Biography

Dr. Nicolas Dumont obtained his PhD at the Université Laval where he studied the regulatory network between inflammatory cells and skeletal muscles. He did his post-doctoral training at the Ottawa Hospital Research Institute in Dr. Michael Rudnicki’s lab, where he studied muscle stem cell defects in Duchenne Muscular Dystrophy. Dr. Dumont became an assistant professor at the Université de Montréal in 2016, and he established his lab at the CHU Sainte-Justine research center. His research program is divided in 3 axes: 1) characterize the intrinsic mechanisms regulating muscle stem cell fate decision during myogenesis, 2) characterize the impact of rare genetic variants on muscle stem cell function, and 3) investigate novel therapeutic avenues targeting defective muscle stem cells to mitigate muscular dystrophies. Dr. Dumont holds a FRQS Junior-2 award, and his lab is funded by grants from the CIHR, NSERC, ThéCell network, Stem Cell Network, Orphan disease center, and Muscular Dystrophy Canada.


Recent Publications

  1. Sénéchal, C, Fujita, R, Jamet, S, Maiga, A, Dort, J, Orfi, Z et al.. The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool. Cell Rep. 2022.41 (7)111645 PMID:36384129
  2. Raad, S, David, A, Sagniez, M, Paré, B, Orfi, Z, Dumont, NA et al.. iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage. Dis Model Mech. 2022. PMID:36317486
  3. Mashinchian, O, De Franceschi, F, Nassiri, S, Michaud, J, Migliavacca, E, Aouad, P et al.. An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs. EMBO J. 2022.41 (14)e110655 PMID:35703167
  4. Soulez, M, Tanguay, PL, Dô, F, Dort, J, Crist, C, Kotlyarov, A et al.. ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation. J Cell Physiol. 2022.237 (4)2271-2287 PMID:35141958
  5. Fabre, P, Molina, T, Orfi, Z, Dumont, NA. Assessment of Muscle Function Following hiPSC-Derived Myoblast Transplantation in Dystrophic Mice. Curr Protoc. 2022.2 (1)e356 PMID:35085428
  6. Molina, T, Fabre, P, Dumont, NA. Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases. Open Biol. 2021.11 (12)210110 PMID:34875199
  7. Deprez, A, Orfi, Z, Radu, A, He, Y, Ravizzoni Dartora, D, Dort, J et al.. Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching. Clin Sci (Lond). 2021.135 (22)2589-2605 PMID:34750633
  8. Dort, J, Orfi, Z, Fabre, P, Molina, T, Conte, TC, Greffard, K et al.. Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy. Nat Commun. 2021.12 (1)6264 PMID:34716330
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