The Neuromuscular Disease Network for Canada

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Nicolas Dumont

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NMD4C

Université de Montréal, Faculty of Medicine, Department of Rehabilitation

CHU Sainte-Justine research center


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Biography

Dr. Nicolas Dumont obtained his PhD at the Université Laval where he studied the regulatory network between inflammatory cells and skeletal muscles. He did his post-doctoral training at the Ottawa Hospital Research Institute in Dr. Michael Rudnicki’s lab, where he studied muscle stem cell defects in Duchenne Muscular Dystrophy. Dr. Dumont became an assistant professor at the Université de Montréal in 2016, and he established his lab at the CHU Sainte-Justine research center. His research program is divided in 3 axes: 1) characterize the intrinsic mechanisms regulating muscle stem cell fate decision during myogenesis, 2) characterize the impact of rare genetic variants on muscle stem cell function, and 3) investigate novel therapeutic avenues targeting defective muscle stem cells to mitigate muscular dystrophies. Dr. Dumont holds a FRQS Junior-2 award, and his lab is funded by grants from the CIHR, NSERC, ThéCell network, Stem Cell Network, Orphan disease center, and Muscular Dystrophy Canada.

Recent publications

  1. Deprez, A, Orfi, Z, Radu, A, He, Y, Ravizzoni Dartora, D, Dort, J et al.. Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching. Clin Sci (Lond). 2021.135 (22)2589-2605 PMID:34750633
  2. Dort, J, Orfi, Z, Fabre, P, Molina, T, Conte, TC, Greffard, K et al.. Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy. Nat Commun. 2021.12 (1)6264 PMID:34716330
  3. Dort, J, Fabre, P, Molina, T, Dumont, NA. Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases. Stem Cells Int. 2019.2019 4761427 PMID:31396285
  4. Feichtinger, RG, Mucha, BE, Hengel, H, Orfi, Z, Makowski, C, Dort, J et al.. Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy. Genet Med. 2019.21 (11)2521-2531 PMID:31092906
  5. Wang, YX, Feige, P, Brun, CE, Hekmatnejad, B, Dumont, NA, Renaud, JM et al.. EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions. Cell Stem Cell. 2019.24 (3)419-432.e6 PMID:30713094
  6. Duchesne, E, Dufresne, SS, Dumont, NA. Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic. Phys Ther. 2017.97 (8)807-817 PMID:28789470
  7. Dumont, NA, Rudnicki, MA. Characterizing Satellite Cells and Myogenic Progenitors During Skeletal Muscle Regeneration. Methods Mol Biol. 2017.1560 179-188 PMID:28155153
  8. Brun, CE, Dumont, NA. [Cell-autonomous defects in satellite cells impair muscle regeneration in Duchenne muscular dystrophy]. Med Sci (Paris). 2016.32 (10)800-802 PMID:27758734
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