Jean-Philippe Leduc-Gaudet
BSTC Co-Chair (2025)
Assistant Professor, Medical Biology Department at Université du Québec à Trois-Rivières (UQTR)
Email Jean-Philippe
Research Interests: Skeletal muscle atrophy, Muscle disorders, Autophagy, Mitochondrial biology, Metabolic Complication
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Biography
Dr. Leduc-Gaudet is an Assistant Professor in the Medical Biology Department at Université du Québec à Trois-Rivières (UQTR). He completed his bachelor in Kinesiology and his master degree with a particular focus on mitochondrial biology, skeletal pathophysiology and aging at Université du Québec à Montréal. Following his M.Sc., he completed his Ph.D. studying the regulatory roles of autophagy & mitophagy in the maintenance of skeletal muscle health under the supervision of Drs. Hussain and Gouspillou (McGill University), where he received a Vanier Canada Graduate Scholarship. After completion of his Ph.D. in 2020, Dr. Leduc-Gaudet completed a postdoctoral fellow in Dr. Sandri’s lab (U Padova, Italy), working on characterizing novel genes and molecular pathways that control skeletal muscle health. In 2023, Dr. Leduc-Gaudet opened his own lab at UQTR to study novel genes and molecular pathways that affect skeletal muscle health, whole-body metabolism, and longevity. Dr. Leduc-Gaudet research program at UQTR also investigates how dysregulated mitochondrial quality control can be harmful to muscle cells. Indeed, mitochondrial dysfunction is a common underlying feature of many muscle-wasting conditions, including aging and neuromuscular diseases. In his research, Dr. Leduc-Gaudet combines genetic, molecular, cellular and physiological approaches to investigate signalling pathways regulating skeletal muscle mass and function.
Recent Publications
Rihoux, A, Sutton, E, Lee, J, Flewwelling, L, Garibotti, M, Osman, H et al.. 2nd NMD4C basic research summer school on promoting standardized protocols to advance translational research in neuromuscular disorders. J Neuromuscul Dis. 2025. 22143602251408154 PMID:41417778
Marcangeli, V, Girard-Côté, L, Di Leo, V, Roussel, MP, Lawless, C, Charest, O et al.. A 12-Week Strength Training Improves Mitochondrial Respiration, H2O2 Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1. Acta Physiol (Oxf). 2025.241 (12)e70135 PMID:41241935
Morin, E, Doumard, E, Hartnell, LM, Salegi Ansa, B, Leduc-Gaudet, JP, Quillien, A et al.. EMito-Metrix enables automated evaluation of mitochondrial morphology across species. Nat Metab. 2025.7 (11)2179-2182 PMID:41094017
Marcangeli, V, Cefis, M, Hammad, R, Granet, J, Leduc-Gaudet, JP, Gaudreau, P et al.. Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans. Aging Cell. 2025.24 (10)e70191 PMID:41061678
Cefis, M, Marcangeli, V, Hammad, R, Granet, J, Leduc-Gaudet, JP, Gaudreau, P et al.. Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Cell Rep Med. 2025.6 (2)101968 PMID:39933528
Desjardins, K, Taherkhani, S, Méthot, L, Castonguay, V, Leduc-Gaudet, JP. Insights into the influence of high-intensity interval training on skeletal muscle clock gene expression in insulin-resistant individuals. J Physiol. 2024.602 (23)6443-6444 PMID:39159307
Roussel, MP, Ravel-Chapuis, A, Gobin, J, Jasmin, BJ, Leduc-Gaudet, JP, Gagnon, C et al.. Changes in Physiopathological Markers in Myotonic Dystrophy Type 1 Skeletal Muscle: A 3-Year Follow-up Study. J Neuromuscul Dis. 2024.11 (5)981-995 PMID:39031377
Girard-Côté, L, Gallais, B, Gagnon, C, Roussel, MP, Morin, M, Hébert, LJ et al.. Resistance training in women with myotonic dystrophy type 1: a multisystemic therapeutic avenue. Neuromuscul Disord. 2024.40 38-51 PMID:38824906
Sedraoui, S, Leduc-Gaudet, JP, Mayaki, D, Moamer, A, Huck, L, Gouspillou, G et al.. Lack of compensatory mitophagy in skeletal muscles during sepsis. J Physiol. 2024.602 (12)2823-2838 PMID:38748778
Cefis, M, Dargegen, M, Marcangeli, V, Taherkhani, S, Dulac, M, Leduc-Gaudet, JP et al.. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf). 2024.240 (5)e14119 PMID:38400630
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