The Neuromuscular Disease Network for Canada

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Jean-Philippe Leduc-Gaudet

Jean-Philippe Leduc-Gaudet 3x2

NMD4C

Postdoctoral Fellow, Sandri Lab, University of Padova


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Research Interests: Skeletal muscle atrophy, Muscle disorders, Autophagy, Mitochondrial biology, Metabolic Complication

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Biography

Dr. Leduc-Gaudet completed his bachelor in Kinesiology and his master degree with a particular focus on mitochondrial biology, skeletal pathophysiology and aging at Université du Québec à Montréal.

Following his M.Sc., he completed his Ph.D. studying the regulatory roles of autophagy & mitophagy in the maintenance of skeletal muscle health under the supervision of Drs. Hussain and Gouspillou (McGill University), where he received a Vanier Canada Graduate Scholarship.

In his research, Dr. Leduc-Gaudet combines genetic, molecular, cellular and physiological approaches to investigate signalling pathways regulating skeletal muscle mass and function. He is currently a postdoctoral fellow in Dr. Sandri’s lab (U Padova, Italy), working on characterizing novel genes and molecular pathways that control skeletal muscle health. He is currently supported by a FRSQ postdoctoral fellowship. Dr. Leduc-Gaudet enjoys sharing his passion and enthusiasm for research.

Recent publications

Leduc-Gaudet, JP, Hussain, SNA, Barreiro, E, Gouspillou, G. Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. Int J Mol Sci. 2021.22 (15) PMID:34360946

Chaffer, TJ, Cefis, M, Leduc-Gaudet, JP. Circadian control of skeletal muscle adaptations to exercise. J Physiol. 2021. PMID:34339519

Dulac, M, Leduc-Gaudet, JP, Cefis, M, Ayoub, MB, Reynaud, O, Shams, A et al.. Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. J Physiol. 2021.599 (17)4045-4063 PMID:34269418

Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S et al.. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021.17 (1)1-382 PMID:33634751

Chaffer, TJ, Leduc-Gaudet, JP, Moamer, A, Broering, FE, Gouspillou, G, Hussain, SNA et al.. Novel insights into the autonomous role played by vitamin D receptor in the regulation of skeletal muscle mass. J Physiol. 2021.599 (7)1955-1956 PMID:33476041

Leduc-Gaudet, JP, Mayaki, D, Reynaud, O, Broering, FE, Chaffer, TJ, Hussain, SNA et al.. Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. Cells. 2020.9 (6) PMID:32545383

Dulac, M, Leduc-Gaudet, JP, Reynaud, O, Ayoub, MB, Guérin, A, Finkelchtein, M et al.. Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation. J Physiol. 2020.598 (17)3691-3710 PMID:32539155

Leduc-Gaudet, JP, Dulac, M, Reynaud, O, Ayoub, MB, Gouspillou, G. Nicotinamide riboside supplementation to improve skeletal muscle mitochondrial health and whole-body glucose homeostasis: does it actually work in humans?. J Physiol. 2020.598 (4)619-620 PMID:31879956

Janice Sánchez, B, Tremblay, AK, Leduc-Gaudet, JP, Hall, DT, Kovacs, E, Ma, JF et al.. Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy. Nat Commun. 2019.10 (1)4171 PMID:31519904

Moroz, N, Maes, K, Leduc-Gaudet, JP, Goldberg, P, Petrof, BJ, Mayaki, D et al.. Oxidants Regulated Diaphragm Proteolysis during Mechanical Ventilation in Rats. Anesthesiology. 2019.131 (3)605-618 PMID:31408447

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