Jean-Philippe Leduc-Gaudet

Jean-Philippe Leduc-Gaudet profile picture

Assistant Professor, Medical Biology Department at Université du Québec à Trois-Rivières (UQTR)


Email Jean-Philippe

Research Interests: Skeletal muscle atrophy, Muscle disorders, Autophagy, Mitochondrial biology, Metabolic Complication

Google Scholar profile
LinkedIn profile
ResearchGate profile
ORCiD profile
Twitter profile

Biography

Dr. Leduc-Gaudet is an Assistant Professor in the Medical Biology Department at Université du Québec à Trois-Rivières (UQTR). He completed his bachelor in Kinesiology and his master degree with a particular focus on mitochondrial biology, skeletal pathophysiology and aging at Université du Québec à Montréal. Following his M.Sc., he completed his Ph.D. studying the regulatory roles of autophagy & mitophagy in the maintenance of skeletal muscle health under the supervision of Drs. Hussain and Gouspillou (McGill University), where he received a Vanier Canada Graduate Scholarship. After completion of his Ph.D. in 2020, Dr. Leduc-Gaudet completed a postdoctoral fellow in Dr. Sandri’s lab (U Padova, Italy), working on characterizing novel genes and molecular pathways that control skeletal muscle health. In 2023, Dr. Leduc-Gaudet opened his own lab at UQTR to study novel genes and molecular pathways that affect skeletal muscle health, whole-body metabolism, and longevity. Dr. Leduc-Gaudet research program at UQTR also investigates how dysregulated mitochondrial quality control can be harmful to muscle cells. Indeed, mitochondrial dysfunction is a common underlying feature of many muscle-wasting conditions, including aging and neuromuscular diseases. In his research, Dr. Leduc-Gaudet combines genetic, molecular, cellular and physiological approaches to investigate signalling pathways regulating skeletal muscle mass and function.


Recent Publications

Cefis, M, Dargegen, M, Marcangeli, V, Taherkhani, S, Dulac, M, Leduc-Gaudet, JP et al.. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf). 2024.240 (5)e14119 PMID:38400630

Leduc-Gaudet, JP, Miguez, K, Cefis, M, Faitg, J, Moamer, A, Chaffer, TJ et al.. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. iScience. 2023.26 (8)107475 PMID:37588163

Leduc-Gaudet, JP, Guirguis, C, Sincennes, MC. [Emerging links between metabolism and epigenetic regulation of muscle stem cells]. Med Sci (Paris). 2023.39 (6-7)530-536 PMID:37387661

Franco-Romero, A, Leduc-Gaudet, JP, Hussain, SN, Gouspillou, G, Sandri, M. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. Autophagy. 2023. 1-3 PMID:37309183

Leduc-Gaudet, JP, Franco-Romero, A, Cefis, M, Moamer, A, Broering, FE, Milan, G et al.. MYTHO is a novel regulator of skeletal muscle autophagy and integrity. Nat Commun. 2023.14 (1)1199 PMID:36864049

Reynaud, O, Wang, J, Ayoub, MB, Leduc-Gaudet, JP, Mayaki, D, Dulac, M et al.. The impact of high-fat feeding and parkin overexpression on skeletal muscle mass, mitochondrial respiration, and H2O2 emission. Am J Physiol Cell Physiol. 2023.324 (2)C366-C376 PMID:36571445

Leduc-Gaudet, JP, Hussain, SN, Gouspillou, G. Parkin: a potential target to promote healthy ageing. J Physiol. 2022.600 (15)3405-3421 PMID:35691026

Gusev, E, Liang, F, Bhattarai, S, Broering, FE, Leduc-Gaudet, JP, Hussain, SN et al.. Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice. Am J Physiol Regul Integr Comp Physiol. 2022.322 (6)R551-R561 PMID:35411814

Leduc-Gaudet, JP, Hussain, SNA. Muscle Wasting in Chronic Obstructive Pulmonary Disease: Not Enough Autophagy?. Am J Respir Cell Mol Biol. 2022.66 (6)587-588 PMID:35294850

Leduc-Gaudet, JP, Hussain, SNA, Barreiro, E, Gouspillou, G. Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. Int J Mol Sci. 2021.22 (15) PMID:34360946

See more on PubMed