Kessen Patten
Working Group Member
Professor - Centre Armand-Frappier Santé Biotechnologie
Institut National de la Recherche Scientifique (INRS)
NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science
Email KessenBiography
Dr. Kessen Patten is an Associate Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.
The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases (ALS and SMA) to understand disease mechanisms and for drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.
Recent Publications
Mencacci, NE, Minakaki, G, Maroofian, R, De Pace, R, Paimboeuf, A, Shannon, P et al.. Pathogenic variants in BORCS5 Cause a Spectrum of Neurodevelopmental and Neurodegenerative Disorders with Lysosomal Dysfunction. medRxiv. 2025. PMID:40385417
McDermott, A, Juárez, M, Wade, MG, Patten, SA, Plante, I. Exposure to brominated flame retardants during pregnancy and lactation increases the prevalence of breast lesions and cancer-associated pathways in sprague-dawley rats. Reprod Toxicol. 2025.135 108928 PMID:40316034
Abdel-Hamid, MS, Paimboeuf, A, Zaki, MS, Figueiredo, F, Abdel-Ghafar, SF, Maher, S et al.. Biallelic variants in GTF3C3 encoding a subunit of the TFIIIC2 complex are associated with neurodevelopmental phenotypes in humans and zebrafish. Brain Commun. 2025.7 (1)fcaf055 PMID:40040844
Counil, H, Silva, RO, Rabanel, JM, Zaouter, C, Haddad, M, Ben Khedher, MR et al.. Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation. J Extracell Biol. 2025.4 (1)e70027 PMID:39830834
Phan, QT, Rabanel, JM, Mekhjian, D, Saber, J, Garcia Ac, A, Zhang, H et al.. Core-Shell Bottlebrush Polymers: Unmatched Delivery of Small Active Compounds Deep Into Tissues. Small. 2025.21 (5)e2408616 PMID:39679753
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