Kessen Patten

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Working Group Member

Professor - Centre Armand-Frappier Santé Biotechnologie

Institut National de la Recherche Scientifique (INRS)


NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science

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Biography

Dr. Kessen Patten is an Associate Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.

 

The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases (ALS and SMA) to understand disease mechanisms and for drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.


Recent Publications

Phan, QT, Rabanel, JM, Mekhjian, D, Saber, J, Garcia Ac, A, Zhang, H et al.. Core-Shell Bottlebrush Polymers: Unmatched Delivery of Small Active Compounds Deep Into Tissues. Small. 2024. e2408616 PMID:39679753

Sow, AA, Jamadagni, P, Scaturro, P, Patten, SA, Chatel-Chaix, L. A zebrafish-based in vivo model of Zika virus infection unveils alterations of the glutamatergic neuronal development and NS4A as a key viral determinant of neuropathogenesis. PLoS Pathog. 2024.20 (12)e1012756 PMID:39621753

Silva, RO, Haddad, M, Counil, H, Zaouter, C, Patten, SA, Fulop, T et al.. Exploring the potential of plasma and adipose mesenchymal stem cell-derived extracellular vesicles as novel platforms for neuroinflammation therapy. J Control Release. 2024.377 880-898 PMID:39617173

McDermott, A, Bernier, C, Piché, V, Plante, I, Patten, SA. Exposure to an environmentally representative mixture of polybrominated diphenyl ethers (PBDEs) alters zebrafish neuromuscular development. Neurotoxicology. 2024.105 247-256 PMID:39490620

Lescouzères, L, Patten, SA. Promising animal models for amyotrophic lateral sclerosis drug discovery: a comprehensive update. Expert Opin Drug Discov. 2024.19 (10)1213-1233 PMID:39115327

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