Kessen Patten
Working Group Member
Associate Professor - Centre Armand-Frappier Santé Biotechnologie
Institut National de la Recherche Scientifique (INRS)
NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science
Email KessenBiography
Dr. Kessen Patten is an Professor at the INRS-Institut Armand Frappier in Canada. He did his PhD in Physiology and Cell Biology at the University of Alberta, followed by two postdoctoral trainings at the Université de Montreal. During his academic training, Dr. Patten has provided new insights in mechanisms of synaptic development using zebrafish, discovered a new gene associated with idiopathic scoliosis and identified neuroleptics as potential therapeutics for amyotrophic lateral sclerosis (ALS), with one compound currently in clinical trial.
The Patten lab uses the zebrafish to model developmental genetic disorders and neuromuscular diseases (ALS and SMA) to understand disease mechanisms and for drug discovery. Dr. Patten is the recipient of the ALS Canada and Brain Canada Career transition award as well as a Fonds de recherche du Québec – Santé (FRQS) Junior 2 Research Scholar. He also holds the Anna Sforza Djoukhadjian Research Chair in ALS.
Recent Publications
Gomes, YCP, Sow, AA, Patten, SA, Chatel-Chaix, L. Quantification of Neural Progenitor Cells From Zika Virus-Infected Zebrafish Embryos. Bio Protoc. 2025.15 (13)e5377 PMID:40655417
Nobilleau, F, Audet, S, da Silva Babinet, A, Tork, S, Zaouter, C, Liao, M et al.. RFC1 regulates the expansion of neural progenitors in the developing zebrafish cerebellum. Nat Commun. 2025.16 (1)6019 PMID:40595562
Maher, S, Langlois Bernard, E, Zaouter, C, Patten, SA. MED27 function is essential for cerebellar development and motor behaviour. Brain. 2025. PMID:40578305
Mencacci, NE, Minakaki, G, Maroofian, R, De Pace, R, Paimboeuf, A, Shannon, P et al.. Pathogenic variants in BORCS5 Cause a Spectrum of Neurodevelopmental and Neurodegenerative Disorders with Lysosomal Dysfunction. medRxiv. 2025. PMID:40385417
McDermott, A, Juárez, M, Wade, MG, Patten, SA, Plante, I. Exposure to brominated flame retardants during pregnancy and lactation increases the prevalence of breast lesions and cancer-associated pathways in sprague-dawley rats. Reprod Toxicol. 2025.135 108928 PMID:40316034
See more on PubMed