The Neuromuscular Disease Network for Canada

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Louise Moyle

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NMD4C

Post Doctoral Research Fellow, Institute of Biomedical Engineering (IBME), University of Toronto


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Biography

Dr. Louise Moyle is a postdoctoral fellow at the Institute of Biomedical Engineering at the University of Toronto, Canada. Her research investigates mechanisms of muscle stem cell dysfunction in neuromuscular disorders, with the aim of transferring this knowledge towards future cell and gene therapies. She completed her PhD in Dr. Peter Zammit’s lab at King’s College London (UK), where she investigated muscle stem cell regeneration in facioscapulohumeral muscular dystrophy (FSHD). She then spent 3 years completing a postdoc with Dr. Francesco Saverio Tedesco at University College London (UK) in stem cell trans-differentiation and disease modelling. She is currently working in the laboratory of Dr. Penney Gilbert, where she is supported by a Medicine by Design postdoctoral fellowship. This research aims to understand how mechanosensing via the LINC complex contributes to the process muscle stem cell repair, with relevance to Emery-Dreifuss muscular dystrophy.

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Recent publications

Ebrahimi, M, Lad, H, Fusto, A, Tiper, Y, Datye, A, Nguyen, CT et al.. De novo revertant fiber formation and therapy testing in a 3D culture model of Duchenne muscular dystrophy skeletal muscle. Acta Biomater. 2021.132 227-244 PMID:34048976

Moyle, LA, Cheng, RY, Liu, H, Davoudi, S, Ferreira, SA, Nissar, AA et al.. Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions. Mol Biol Cell. 2020.31 (16)1703-1713 PMID:32491970

Fusto, A, Moyle, LA, Gilbert, PM, Pegoraro, E. Cored in the act: the use of models to understand core myopathies. Dis Model Mech. 2019.12 (12) PMID:31874912

Moyle, LA, Tedesco, FS, Benedetti, S. Pericytes in Muscular Dystrophies. Adv Exp Med Biol. 2019.1147 319-344 PMID:31147885

Gerli, MFM, Moyle, LA, Benedetti, S, Ferrari, G, Ucuncu, E, Ragazzi, M et al.. Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells. Stem Cell Reports. 2019.12 (3)461-473 PMID:30745033

Maffioletti, SM, Sarcar, S, Henderson, ABH, Mannhardt, I, Pinton, L, Moyle, LA et al.. Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Rep. 2018.23 (3)899-908 PMID:29669293

Benedetti, S, Uno, N, Hoshiya, H, Ragazzi, M, Ferrari, G, Kazuki, Y et al.. Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy. EMBO Mol Med. 2018.10 (2)254-275 PMID:29242210

Tedesco, FS, Moyle, LA, Perdiguero, E. Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle. Methods Mol Biol. 2017.1556 129-147 PMID:28247348

Moyle, LA, Blanc, E, Jaka, O, Prueller, J, Banerji, CR, Tedesco, FS et al.. Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy. Elife. 2016.5 PMID:27841748

Knopp, P, Krom, YD, Banerji, CR, Panamarova, M, Moyle, LA, den Hamer, B et al.. DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis. J Cell Sci. 2016.129 (20)3816-3831 PMID:27744317

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