Nicolas Dumont

Dr. Nicolas Dumont profile picture.

Associate professor, Rehabilitation department, University of Montreal

Principal Investigator, Musculoskeletal health research axis, Sainte-Justine Hospital research center


NMD4C Involvement: Pillar 1: Preclinical Science

Email Nicolas
Academic web profile
Google Scholar profile
ResearchGate profile
Lab website

Biography

Dr. Nicolas Dumont obtained his PhD at the Université Laval where he studied the regulatory network between inflammatory cells and skeletal muscles. He did his post-doctoral training at the Ottawa Hospital Research Institute in Dr. Michael Rudnicki’s lab, where he studied muscle stem cell defects in Duchenne Muscular Dystrophy. Dr. Dumont became an assistant professor at the Université de Montréal in 2016, and he established his lab at the Sainte-Justine hospital research center. His research program is divided in 3 axes: 1) characterizing the intrinsic mechanisms regulating muscle stem cell fate decision during myogenesis, 2) characterizing the impact of rare genetic variants on muscle stem cell function, and 3) investigating novel therapeutic avenues targeting defective muscle stem cells to mitigate muscular dystrophies. Dr. Dumont holds a FRQS Junior-2 award, and his lab is funded by grants from the CIHR, NSERC, ThéCell network, Stem Cell Network, Orphan disease center, AFM-Telethon, and Muscular Dystrophy Canada.


Recent Publications

  1. Rieger, L, Molina, T, Fabre, P, Greffard, K, Pellerito, O, Dort, J et al.. Transcriptomic and lipidomic profiling reveals distinct bioactive lipid signatures in slow and fast muscles and highlights the role of resolvin-D2 in fiber type determination during myogenesis. FASEB J. 2024.38 (24)e70250 PMID:39698915
  2. Deprez, A, El-Jalbout, R, Cloutier, A, Gagnon, DH, Gagnon Hamelin, A, Mathieu, ME et al.. Adults born preterm have lower peripheral skeletal muscle area and strength. Sci Rep. 2024.14 (1)21457 PMID:39271745
  3. Nkengue, MJ, Zeng, X, Koehl, L, Tao, X, Dassonville, F, Dumont, N et al.. An intelligent garment for long COVID-19 real-time monitoring. Comput Biol Med. 2024.181 109067 PMID:39182371
  4. Morali, B, Miranda, V, Raelson, J, Grimard, G, Glavas, P, Audibert, F et al.. Bi-allelic variants in MYH3 cause recessively-inherited arthrogryposis. Clin Genet. 2024.106 (4)483-487 PMID:38856159
  5. Mahdavi, M, Prévost, K, Balthazar, P, Hus, IF, Duchesne, É, Dumont, N et al.. Disturbance of the human gut microbiota in patients with Myotonic Dystrophy type 1. Comput Struct Biotechnol J. 2024.23 2097-2108 PMID:38803516
  6. Le Moal, E, Liu, Y, Collerette-Tremblay, J, Dumontier, S, Fabre, P, Molina, T et al.. Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice. Sci Transl Med. 2024.16 (739)eabn8529 PMID:38507466
  7. Deprez, A, Poletto Bonetto, JH, Ravizzoni Dartora, D, Dodin, P, Nuyt, AM, Luu, TM et al.. Impact of preterm birth on muscle mass and function: a systematic review and meta-analysis. Eur J Pediatr. 2024.183 (5)1989-2002 PMID:38416257
  8. Dort, J, Orfi, Z, Fiscaletti, M, Campeau, PM, Dumont, NA. Gpr18 agonist dampens inflammation, enhances myogenesis, and restores muscle function in models of Duchenne muscular dystrophy. Front Cell Dev Biol. 2023.11 1187253 PMID:37645248
Search PubMed