NMD4C

The neuromuscular network for Canada

Rashmi Kothary

Biography

Dr Rashmi Kothary is the Deputy Scientific Director and Senior Scientist at the Ottawa Hospital Research Institute (OHRI). He received a Ph.D. in Biochemistry from the University of British Columbia and pursued postdoctoral research in the laboratories of Dr. Janet Rossant at the Mount Sinai Hospital Research Institute in Toronto and Dr. Azim Surani in Cambridge, U.K. It was during these formative years that Dr. Kothary developed his interests in pre-clinical models to study disease pathology. In 1990, he returned to Canada to begin his independent research career at the Institut du cancer de Montréal. In 1998, Dr. Kothary joined the Ottawa Hospital Research Institute. He has held the University Health Research Chair in Neuromuscular Disorders and is a Professor at the University of Ottawa. His current research focuses on investigating extrinsic and intrinsic factors important for oligodendrocyte mediated myelination and remyelination of the CNS (in the context of Multiple Sclerosis), and understanding Spinal Muscular Atrophy pathogenesis and identifying novel therapeutics for this devastating children’s disease. He currently sits on the CIHR IMHA advisory board, has served on the scientific advisory board for MDA and Cure SMA, and is a reviewer for the CIHR, NIH and Shriners Hospitals for Children.

Dr. Kothary represents basic science as a member of the NMD4C Steering Committee.

Recent publications

Lynch-Godrei, A, Kothary, R. HSAN-VI: A spectrum disorder based on dystonin isoform expression. Neurol Genet. 2020.6 (1)e389 PMID:32042917

Lynch-Godrei, A, De Repentigny, Y, Yaworski, RA, Gagnon, S, Butcher, J, Manoogian, J et al.. Characterization of gastrointestinal pathologies in the dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI. Neurogastroenterol. Motil. 2019. e13773 PMID:31814231

Alvarez-Saavedra, M, Yan, K, De Repentigny, Y, Hashem, LE, Chaudary, N, Sarwar, S et al.. Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development. Front Mol Neurosci. 2019.12 243 PMID:31680852

Deguise, MO, Chehade, L, Tierney, A, Beauvais, A, Kothary, R. Low fat diets increase survival of a mouse model of spinal muscular atrophy. Ann Clin Transl Neurol. 2019.6 (11)2340-2346 PMID:31608604

Nery, FC, Siranosian, JJ, Rosales, I, Deguise, MO, Sharma, A, Muhtaseb, AW et al.. Impaired kidney structure and function in spinal muscular atrophy. Neurol Genet. 2019.5 (5)e353 PMID:31517062

Galloway, DA, Gowing, E, Setayeshgar, S, Kothary, R. Inhibitory milieu at the multiple sclerosis lesion site and the challenges for remyelination. Glia. 2019. PMID:31441132

Deguise, MO, Baranello, G, Mastella, C, Beauvais, A, Michaud, J, Leone, A et al.. Abnormal fatty acid metabolism is a core component of spinal muscular atrophy. Ann Clin Transl Neurol. 2019.6 (8)1519-1532 PMID:31402618

Eshraghi, M, Gombar, R, De Repentigny, Y, Vacratsis, PO, Kothary, R. Pathologic Alterations in the Proteome of Synaptosomes from a Mouse Model of Spinal Muscular Atrophy. J. Proteome Res. 2019.18 (8)3042-3051 PMID:31262178

Chardon, JW, Jasmin, BJ, Kothary, R, Parks, RJ. Report on the 4th Ottawa International Conference on Neuromuscular Disease and Biology - September 5-7, 2017, Ottawa, Canada. J Neuromuscul Dis. 2018.5 (4)539-552 PMID:30373960

De Repentigny, Y, Kothary, R. Surgical Artificial Insemination in Mice. Cold Spring Harb Protoc. 2018.2018 (9) PMID:30181219

See more on PubMed