The Neuromuscular Disease Network for Canada


Rashmi Kothary


Deputy Scientific Director and Senior Scientist, Ottawa Hospital Research Institute

Professor, University of Ottawa

NMD4C Working Group(s): Biobanking, Early Career

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Dr Rashmi Kothary is the Deputy Scientific Director and Senior Scientist at the Ottawa Hospital Research Institute (OHRI). He received a Ph.D. in Biochemistry from the University of British Columbia and pursued postdoctoral research in the laboratories of Dr. Janet Rossant at the Mount Sinai Hospital Research Institute in Toronto and Dr. Azim Surani in Cambridge, U.K. It was during these formative years that Dr. Kothary developed his interests in pre-clinical models to study disease pathology. In 1990, he returned to Canada to begin his independent research career at the Institut du cancer de Montréal. In 1998, Dr. Kothary joined the Ottawa Hospital Research Institute. He has held the University Health Research Chair in Neuromuscular Disorders and is a Professor at the University of Ottawa. His current research focuses on investigating extrinsic and intrinsic factors important for oligodendrocyte mediated myelination and remyelination of the CNS (in the context of Multiple Sclerosis), and understanding Spinal Muscular Atrophy pathogenesis and identifying novel therapeutics for this devastating children’s disease. He currently sits on the SMA Beyond advisory board, has served on the scientific advisory board for CIHR IMHA, MDA and Cure SMA, and is a reviewer for the CIHR, NIH and Shriners Hospitals for Children.

Dr. Kothary represents basic science as a member of the NMD4C Steering Committee.

Recent Publications

Ngo, C, Kothary, R. MicroRNAs in oligodendrocyte development and remyelination. J Neurochem. 2022. PMID:35536759

Reilly, A, Deguise, MO, Beauvais, A, Yaworski, R, Thebault, S, Tessier, DR et al.. Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy. Gene Ther. 2022. PMID:35462564

Khayrullina, G, Alipio-Gloria, ZA, Deguise, MO, Gagnon, S, Chehade, L, Stinson, M et al.. Survival motor neuron protein deficiency alters microglia reactivity. Glia. 2022.70 (7)1337-1358 PMID:35373853

Deguise, MO, Chehade, L, Kothary, R. Metabolic Dysfunction in Spinal Muscular Atrophy. Int J Mol Sci. 2021.22 (11) PMID:34072857

Deguise, MO, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L et al.. SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease. Cell Mol Gastroenterol Hepatol. 2021.12 (1)354-377.e3 PMID:33545428

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