The Neuromuscular Disease Network for Canada


Rashmi Kothary


Deputy Scientific Director and Senior Scientist, Ottawa Hospital Research Institute

Professor, University of Ottawa

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Dr Rashmi Kothary is the Deputy Scientific Director and Senior Scientist at the Ottawa Hospital Research Institute (OHRI). He received a Ph.D. in Biochemistry from the University of British Columbia and pursued postdoctoral research in the laboratories of Dr. Janet Rossant at the Mount Sinai Hospital Research Institute in Toronto and Dr. Azim Surani in Cambridge, U.K. It was during these formative years that Dr. Kothary developed his interests in pre-clinical models to study disease pathology. In 1990, he returned to Canada to begin his independent research career at the Institut du cancer de Montréal. In 1998, Dr. Kothary joined the Ottawa Hospital Research Institute. He has held the University Health Research Chair in Neuromuscular Disorders and is a Professor at the University of Ottawa. His current research focuses on investigating extrinsic and intrinsic factors important for oligodendrocyte mediated myelination and remyelination of the CNS (in the context of Multiple Sclerosis), and understanding Spinal Muscular Atrophy pathogenesis and identifying novel therapeutics for this devastating children’s disease. He currently sits on the CIHR IMHA advisory board, has served on the scientific advisory board for MDA and Cure SMA, and is a reviewer for the CIHR, NIH and Shriners Hospitals for Children.

Dr. Kothary represents basic science as a member of the NMD4C Steering Committee.

Recent publications

Pringle, CE, Nelson, R, Miller, W, Kothary, R, Michaud, J. Spinal muscular atrophy type III complicated by spinal superficial siderosis: a case report with molecular and neuropathological findings. Acta Neuropathol Commun. 2020.8 (1)188 PMID:33168084

Kosaraju, J, Seegobin, M, Gouveia, A, Syal, C, Sarma, SN, Lu, KJ et al.. Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation. Exp Neurol. 2020.334 113454 PMID:32877653

Wassmer, SJ, De Repentigny, Y, Sheppard, D, Lagali, PS, Fang, L, Coupland, SG et al.. XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy. Invest Ophthalmol Vis Sci. 2020.61 (8)49 PMID:32735323

Kornfeld, SF, Cummings, SE, Fathi, S, Bonin, SR, Kothary, R. MiRNA-145-5p prevents differentiation of oligodendrocyte progenitor cells by regulating expression of myelin gene regulatory factor. J Cell Physiol. 2021.236 (2)997-1012 PMID:32602617

Deguise, MO, De Repentigny, Y, Tierney, A, Beauvais, A, Michaud, J, Chehade, L et al.. Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy. EBioMedicine. 2020.55 102750 PMID:32339936

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