Rashmi Kothary

Dr. Rashmi Kothary 4x3

Preclinical Science Co-Lead & Steering Committee Member

Senior Scientist, Ottawa Hospital Research Institute

Professor, University of Ottawa


NMD4C Involvement: Pillar 1: Preclinical Science, Theme 5: Open Science

Email Rashmi

Biography

Dr. Kothary a Senior Scientist at the Ottawa Hospital Research Institute (OHRI). He has held the University Health Research Chair in Neuromuscular Disorders and is a Professor at the University of Ottawa. He has been instrumental in many leadership initiatives, including the creation, with Dr. Bernard Jasmin, of the University of Ottawa Centre for Neuromuscular Disease (CNMD). Today, this center represents the preeminent collection of neuromuscular disease researchers in Canada, bringing together more than 55 basic and clinical scientists working on a variety of disorders.

His current research focuses on investigating factors important for oligodendrocyte mediated myelination and remyelination of the CNS (in the context of Multiple Sclerosis) and understanding spinal muscular atrophy (SMA) pathogenesis to identify novel therapeutics for this devastating children’s disease. In this regard, his group is demonstrating that SMA is a multisystem disorder, and that it is critical to develop whole body therapies when treating patients.

He presently sits on the scientific advisory boards of SMA Beyond (which is based in Europe) and Cure SMA USA. Previously, he has served on the scientific advisory board for CIHR Institute of Musculoskeletal Health and Arthritis and Muscular Dystrophy Association USA, and currently is a reviewer for the CIHR, NIH, MDA and Shriners Hospitals for Children. 

He represents basic science as a member of the NMD4C Steering Committee and is a Pillar 1: Preclinical Science Co-Lead.


Recent Publications

Sutton, ER, Beauvais, A, Yaworski, R, McMillan, HJ, Kothary, R. Maternal-Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy. Ann Neurol. 2026. PMID:42458739

Her, YR, Fuentes-Moliz, A, Kothary, R, Tabares, L, Monani, UR. Multiple spinal muscular atrophy disease-modifying effects of a Hspa8G470R synaptic chaperone variant. Brain. 2026. PMID:42343572

Poulin, KL, René, CA, Smith, IC, Vacratsis, PO, Burger, D, McMillan, HJ et al.. Extracellular vesicles as biomarkers of disease progression and therapeutic response in patients with spinal muscular atrophy. Mol Ther Adv. 2026.34 (2)201757 PMID:42232219

Garner, R, Ha, LL, Nery, FC, Spellman, RG, Chehade, L, Eichelberger, EJ et al.. Cardiac defects in spinal muscular atrophy and the role of SMN in cardiomyocyte homeostasis. bioRxiv. 2026. PMID:41928955

Her, YR, Fuentes-Moliz, A, Kothary, R, Tabares, L, Monani, UR. Protein-stabilizing and neurotransmission-potentiating activities of a synaptic chaperone modify spinal muscular atrophy in model mice. bioRxiv. 2026. PMID:41884563

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