Agessandro Abrahao

Dr. Agessandro Abrahao

Co-Applicant

Assistant Professor of Medicine (Neurology) at  University of Toronto | Staff Neurologist at Sunnybrook Health Sciences Centre

Associate Scientist at Sunnybrook Health Sciences Centre


NMD4C Involvement: Pillar 2: Clinical Research, Pillar 3: Clinical Practice Research

Email Agessandro

Research Interests: ALS, clinical trials, drug development, Neurophysiological biomarkers, MR-guided focused ultrasound for neurological diseases

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Biography

Agessandro Abrahao, MD, is an academic neurologist with MSc degree in Neuroscience from the Federal University of Sao Paulo, Brazil and in Clinical Epidemiology from the Institute of Health Policy, Management and Evaluation, University of Toronto. He completed an advanced fellowship training in ALS/ Neuromuscular Diseases at Sunnybrook Health Sciences Centre – University of Toronto and is certified in EMG techniques by the Canadian Society of Clinical Neurophysiologists. Agessandro also served as the inaugural Sunnybrook Neuromodulation/Focused Ultrasound Fellow. 

Agessandro’s research aims to accelerate the drug development and clinical trials for ALS. His research interests also include clinical trials and epidemiological studies in ALS and other neuromuscular disorders. He is also interested in the development of biomarkers for motor neuron function using transcranial magnetic stimulation and motor unit count techniques. 


Recent Publications

Parks, ASE, Gotlib Conn, L, Amog, K, Bodmer, NS, King, JW, McLaren, AMR et al.. Age and life stage in the experience of amyotrophic lateral sclerosis: a scoping review. Amyotroph Lateral Scler Frontotemporal Degener. 2025. 1-27 PMID:40511793

Tankisi, H, Jacobsen, AB, Fanella, G, Cengiz, B, Kılınç, H, Matamala, JM et al.. Short-interval intracortical inhibition and facilitation in amyotrophic lateral sclerosis related to disease phenotype. Clin Neurophysiol. 2025.176 2110770 PMID:40482593

Pommée, T, Bouvier, L, Barnett-Tapia, C, Maffei, MF, Gutz, SE, Tilton-Bolowsky, VE et al.. Construct Validity of the Amyotrophic Lateral Sclerosis Bulbar Dysfunction Index-Remote. Am J Speech Lang Pathol. 2025. 1-23 PMID:40460399

Truong, J, Simmatis, L, Pommée, T, Abrahao, A, Adams, K, Chum, M et al.. Differentiating upper- and lower motor neuron diseases using automated acoustic analysis. Amyotroph Lateral Scler Frontotemporal Degener. 2025. 1-11 PMID:40450589

Montero-Odasso, M, Pieruccini-Faria, F, Black, SE, Binns, MA, Freedman, M, Grimes, DA et al.. Association between vascular risk factors burden and neurodegenerative diseases: results from ONDRI. J Neurol. 2025.272 (6)418 PMID:40413670

Broberg, DN, Haddad, SMH, Aveni, K, Havens, A, McLaughlin, PM, Binns, MA et al.. White matter tract correlations with spoken language in cerebrovascular disease. Brain Commun. 2025.7 (3)fcaf145 PMID:40351387

Boshmaf, SZ, Petersen, J, Kumar, R, Scantlebury, N, Rohringer, CR, Triantafilou, A et al.. Cognitive Outcomes Following Second-Sided Focused Ultrasound Thalamotomy for Tremor. Mov Disord Clin Pract. 2025. PMID:40265993

Faerman, MV, Cole, C, Van Ooteghem, K, Cornish, BF, Howe, EE, Siu, V et al.. Motor, affective, cognitive, and perceptual symptom changes over time in individuals with Parkinson's disease who develop freezing of gait. J Neurol. 2025.272 (5)321 PMID:40198411

Mirceta, M, Schmidt, MHM, Shum, N, Prasolava, TK, Meikle, B, Lanni, S et al.. C9orf72 repeat expansion creates the unstable folate-sensitive fragile site FRA9A. NAR Mol Med. 2024.1 (4)ugae019 PMID:39669124

Zinman, L, Duni, E, Abrahao, A. Rethinking Drug Reimbursement Criteria in Amyotrophic Lateral Sclerosis. Can J Neurol Sci. 2024.51 (5)606-607 PMID:39630042

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