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Myogenesis Discussion Group | Myomaker and Ether Lipids Cooperate to Promote Fusion-Competent Membrane States
Myogenesis Discussion Group: A seminar series on skeletal, cardiac and smooth muscle research held on the last Monday of each month.
Speaker
Dr. Tanner Wherley | Millay Lab, Division of Molecular Cardiovascular Biology,
Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
(Click to view/Close the speaker’s bio)
Tanner J. Wherley, PhD, recently completed doctoral training under the supervision of Dr. Doug Millay. This research focuses on defining lipid-dependent mechanisms that regulate skeletal muscle cell fusion. The muscle-specific fusogens Myomaker and Myomerger are essential for plasma membrane fusion of muscle cells; however, a mechanistic understanding of Myomaker activity is lacking. Ether-linked phospholipids were identified as modulators of Myomaker function. Elevation of ether lipids in Myomaker-expressing cells promoted fusion independent of Myomerger and correlated with increased surface exposure of phosphatidylethanolamine and phosphatidylserine, indicating remodeling of plasma membrane lipid distribution. Together, these findings link ether lipid metabolism to the molecular machinery driving muscle cell fusion, with broad implications for skeletal muscle biology.
Details
Title: Myomaker and Ether Lipids Cooperate to Promote Fusion-Competent Membrane States
Date: Monday, 26 January 2026
Time: 2-3pm EST
To register please email the event organizer
Learn more at https://mbd.ccrm.ca/research/discussion-groups/, and follow Myogenesis Discussion Group on Twitter @MyogenesisGroup