Agessandro Abrahao

Dr. Agessandro Abrahao

Co-Applicant

Assistant Professor of Medicine (Neurology) at  University of Toronto | Staff Neurologist at Sunnybrook Health Sciences Centre

Associate Scientist at Sunnybrook Health Sciences Centre


NMD4C Involvement: Pillar 2: Clinical Research, Pillar 3: Clinical Practice Research

Email Agessandro

Research Interests: ALS, clinical trials, drug development, Neurophysiological biomarkers, MR-guided focused ultrasound for neurological diseases

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Biography

Agessandro Abrahao, MD, is an academic neurologist with MSc degree in Neuroscience from the Federal University of Sao Paulo, Brazil and in Clinical Epidemiology from the Institute of Health Policy, Management and Evaluation, University of Toronto. He completed an advanced fellowship training in ALS/ Neuromuscular Diseases at Sunnybrook Health Sciences Centre – University of Toronto and is certified in EMG techniques by the Canadian Society of Clinical Neurophysiologists. Agessandro also served as the inaugural Sunnybrook Neuromodulation/Focused Ultrasound Fellow. 

Agessandro’s research aims to accelerate the drug development and clinical trials for ALS. His research interests also include clinical trials and epidemiological studies in ALS and other neuromuscular disorders. He is also interested in the development of biomarkers for motor neuron function using transcranial magnetic stimulation and motor unit count techniques. 


Recent Publications

Mirceta, M, Schmidt, MHM, Shum, N, Prasolava, TK, Meikle, B, Lanni, S et al.. C9orf72 repeat expansion creates the unstable folate-sensitive fragile site FRA9A. NAR Mol Med. 2024.1 (4)ugae019 PMID:39669124

Zinman, L, Duni, E, Abrahao, A. Rethinking Drug Reimbursement Criteria in Amyotrophic Lateral Sclerosis. Can J Neurol Sci. 2024.51 (5)606-607 PMID:39630042

Mirceta, M, Schmidt, MHM, Shum, N, Prasolava, TK, Meikle, B, Lanni, S et al.. C9orf72 expansion creates the unstable folate-sensitive fragile site FRA9A. bioRxiv. 2024. PMID:39569145

Petersen, J, McGough, J, Gopinath, G, Scantlebury, N, Tripathi, R, Brandmeir, C et al.. Cognitive outcomes following unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: findings from two cohorts. Brain Commun. 2024.6 (5)fcae293 PMID:39291168

Müller, HP, Abrahao, A, Beaulieu, C, Benatar, M, Dionne, A, Genge, A et al.. Temporal and spatial progression of microstructural cerebral degeneration in ALS: A multicentre longitudinal diffusion tensor imaging study. Neuroimage Clin. 2024.43 103633 PMID:38889523

Tsai, CC, Tao, B, Wong, M, Suntharalingam, H, Abrahao, A, Barnett-Tapia, C et al.. Sex, racial, and ethnic disparities in motor neuron disease: clinical trial enrolment. Amyotroph Lateral Scler Frontotemporal Degener. 2024.25 (7-8)694-701 PMID:38835201

Benatar, M, Hansen, T, Rom, D, Geist, MA, Blaettler, T, Camu, W et al.. Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial. Lancet Neurol. 2024.23 (7)687-699 PMID:38782015

Hamani, C, Davidson, B, Lipsman, N, Abrahao, A, Nestor, SM, Rabin, JS et al.. Insertional effect following electrode implantation: an underreported but important phenomenon. Brain Commun. 2024.6 (3)fcae093 PMID:38707711

Gopinath, G, Scantlebury, N, Sewell, IJ, Rohringer, CR, Sivadas, S, McSweeney, M et al.. Changes in Caregiver Burden Following Unilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor. Mov Disord Clin Pract. 2024.11 (7)905-908 PMID:38576099

Scantlebury, N, Rabin, JS, De Schlichting, E, Hamani, C, Schwartz, ML, Lipsman, N et al.. Reply: Evaluating the Scope and Safety of Bilateral MRgFUS Thalamotomy for Essential Tremor: A Critical Analysis. Mov Disord Clin Pract. 2024.11 (3)320-321 PMID:38169118

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