Agessandro Abrahao

Agessandro Abrahao

Co-Applicant

Assistant Professor of Medicine (Neurology) at  University of Toronto | Staff Neurologist at Sunnybrook Health Sciences Centre

Associate Scientist at Sunnybrook Health Sciences Centre


NMD4C Involvement: Pillar 2: Clinical Research, Pillar 3: Clinical Practice Research

Email Agessandro

Research Interests: ALS, clinical trials, drug development, Neurophysiological biomarkers, MR-guided focused ultrasound for neurological diseases

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Biography

Agessandro Abrahao, MD, is an academic neurologist with MSc degree in Neuroscience from the Federal University of Sao Paulo, Brazil and in Clinical Epidemiology from the Institute of Health Policy, Management and Evaluation, University of Toronto. He completed an advanced fellowship training in ALS/ Neuromuscular Diseases at Sunnybrook Health Sciences Centre – University of Toronto and is certified in EMG techniques by the Canadian Society of Clinical Neurophysiologists. Agessandro also served as the inaugural Sunnybrook Neuromodulation/Focused Ultrasound Fellow. 

Agessandro’s research aims to accelerate the drug development and clinical trials for ALS. His research interests also include clinical trials and epidemiological studies in ALS and other neuromuscular disorders. He is also interested in the development of biomarkers for motor neuron function using transcranial magnetic stimulation and motor unit count techniques. 


Recent Publications

Arora, T, Almokdad, M, Sorensen, DM, Abrahao, A, Alaamel, A, Alaydin, HC et al.. Reliability and Agreement of CMAP Scan-Derived MUNE Algorithms in Healthy Individuals. IEEE Trans Biomed Eng. 2026.PP PMID:42658694

Halabian, N, Park, C, Omoto, L, Bocca, LF, Palacios, G, Wu, K et al.. Focused ultrasound blood brain barrier opening for targeted therapeutics in neurodegenerative diseases. Biol Psychiatry. 2026. PMID:42468901

Parks, ASE, Conn, LG, Abrahao, A, Zinman, L, Sale, JEM. "Straddling two worlds": complexities of spousal caregiving in amyotrophic lateral sclerosis during younger middle age. BMC Palliat Care. 2026. PMID:42436431

Huynh, A, Cranley, L, Barnett-Tapia, C, Abrahao, A, Zinman, L, Yunusova, Y et al.. Understanding patients' experiences and needs around decision-making for bulbar symptom management at a multidisciplinary ALS clinic. Disabil Rehabil. 2026. 1-16 PMID:42385017

Sarica, C, Darmani, G, Ramezanpour, H, Callister, M, Santyr, B, Grippe, T et al.. Transcranial ultrasound stimulation of motor networks in Parkinson's disease informed by local field potential dynamics. Sci Transl Med. 2026.18 (850)eady1883 PMID:42160449

Tchoudnovski, D, Yang, D, Ntale, I, Xie, H, Zinman, L, Izenberg, A et al.. Depressive symptoms, but not OSA severity, are associated with general fatigue in myasthenia gravis. Sleep Med. 2026.144 108970 PMID:42070450

Saldanha-Castro, P, Vyas, MV, Jain, D, Santos-Neto, D, Mirian, A, Pooled Resource Open-Access ALS Clinical Trials Consortium et al.. Association between statin use and survival in patients with ALS: A propensity score-matched analysis. J Neurol Sci. 2026.486 125916 PMID:42013513

Katzberg, HD, Bril, V, Zinman, L, Abrahao, A, Cherney, D, Shah, H et al.. The Muscle Cramp Impact Index: A Patient-Centered Scale for the Assessment of Muscle Cramps. Neurology. 2026.106 (9)e214835 PMID:41955555

Kapustin, D, Rashidi-Ranjbar, N, Wang, W, Binns, MA, McLaughlin, PM, Abrahao, A et al.. Neuropsychiatric Symptom Clusters and Their Association With Brain Structure in Alzheimer Disease. J Clin Psychiatry. 2026.87 (2) PMID:41871235

Shafie, M, Tamba, C, Bhinder, H, Canadian ALS Neuroimaging Consortium (CALSNIC), Kalra, S, Pizzagalli, F et al.. Brain Folding Trajectories in Amyotrophic Lateral Sclerosis. Hum Brain Mapp. 2026.47 (4)e70449 PMID:41795629

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