Aymeric Ravel-Chapuis
Co-Applicant
Assistant Professor in the School of Pharmaceutical Sciences at the University of Ottawa
NMD4C Involvement: Pillar 1: Preclinical Science
Email AymericResearch Interests: Neuromuscular disorders, Myotonic Dystrophy, Cell signaling, Post-transcriptional regulations, Myosecretome, Novel therapeutic strategies
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Biography
Dr. Ravel-Chapuis is an Assistant Professor in the School of Pharmaceutical Sciences at the University of Ottawa. He received his PhD from the Ecole Normale Supérieure de Lyon (France), focusing on the role of epigenetic modifications as regulators of gene expression in skeletal muscle. He next completed a postdoctoral fellowship at the University of Ottawa, studying the involvement of RNA-binding proteins in Myotonic Dystrophy type 1 (DM1). Subsequently, he pursued his research as a research associate, characterizing cell signaling dysfunction in DM1 and developing new pharmacological approaches to improve the disease phenotype. In 2022, Dr. Ravel-Chapuis started a new independent research program at the University of Ottawa, investigating the role of the myosecretome in the context of DM1 and other neuromuscular disorders.
Recent Publications
Neault, N, Ravel-Chapuis, A, Baird, SD, Lunde, JA, Poirier, M, Staykov, E et al.. Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model. Int J Mol Sci. 2023.24 (4) PMID:36835205
Osseni, A, Ravel-Chapuis, A, Belotti, E, Scionti, I, Gangloff, YG, Moncollin, V et al.. Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation. Nat Commun. 2022.13 (1)7108 PMID:36402791
van Cruchten, RTP, van As, D, Glennon, JC, van Engelen, BGM, 't Hoen, PAC, OPTIMISTIC consortium et al.. Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood. BMC Med. 2022.20 (1)395 PMID:36352383
Misquitta, NS, Ravel-Chapuis, A, Jasmin, BJ. Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner. Hum Mol Genet. 2023.32 (4)551-566 PMID:36048859
Freeman, E, Langlois, S, Scott, K, Ravel-Chapuis, A, Jasmin, BJ, Cowan, KN et al.. Sex-dependent role of Pannexin 1 in regulating skeletal muscle and satellite cell function. J Cell Physiol. 2022.237 (10)3944-3959 PMID:35938715
Ravel-Chapuis, A, Duchesne, E, Jasmin, BJ. Pharmacological and exercise-induced activation of AMPK as emerging therapies for myotonic dystrophy type 1 patients. J Physiol. 2022.600 (14)3249-3264 PMID:35695045
Ravel-Chapuis, A, Jasmin, BJ. Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects. Trends Mol Med. 2022.28 (6)439-442 PMID:35537989
Ravel-Chapuis, A, Haghandish, A, Daneshvar, N, Jasmin, BJ, Côté, J. A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy. Hum Mol Genet. 2022.31 (9)1453-1470 PMID:34791230
Almasi, S, Crawford Parks, TE, Ravel-Chapuis, A, MacKenzie, A, Côté, J, Cowan, KN et al.. Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells. Cell Oncol (Dordr). 2021.44 (4)851-870 PMID:33899158
Karmouch, J, Delers, P, Semprez, F, Soyed, N, Areias, J, Bélanger, G et al.. AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency. Front Mol Neurosci. 2020.13 568171 PMID:33362463
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