Christopher Perry
Co-Applicant
Associate Professor in the School of Kinesiology and Health Sciences at York University in Toronto, ON, Canada
Associate Director of the Muscle Health Research Centre at York University in Toronto, ON, Canada
NMD4C Involvement: Pillar 1: Preclinical Science
Research Interests: mitochondria, muscle, Duchenne, neuromuscular disease, muscle weakness, reactive oxygen species, oxidative stress, redox biology, metabolism
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Biography
Dr. Christopher Perry is an Associate Professor in the School of Kinesiology and Health Science and Associate Director of the Muscle Health Research Centre at York University in Toronto, Ontario, Canada. His laboratory aims to understand how mitochondrial stress contributes to muscle weakness in a variety of disorders including Duchenne muscular dystrophy.
Ongoing work examines how certain muscles demonstrate dynamic resliency during cancer in an attempt to slow the progression of muscle weakness. Our team has also identified several compounds that partially restore muscle health in a mouse model of Duchenne muscular dystrophy by preserving mitochondrial metabolism. The lab also investigates how exercise improves muscle metabolism in humans and uses this information as the ‘mechanistic template’ for restoring healthy muscle function in diseases.
By working with clinical and industrial partners, the ultimate goal of the lab is to identify metabolic and redox stress-based mechanisms of muscle weakness and apply these findings towards the development of therapeutics that may help people improve muscle health, functional independence and quality of life.
Recent Publications
Delfinis, LJ, Ogilvie, LM, Khajehzadehshoushtar, S, Gandhi, S, Garibotti, MC, Thuhan, AK et al.. Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia. bioRxiv. 2024. PMID:38645227
Bellissimo, CA, Gandhi, S, Castellani, LN, Murugathasan, M, Delfinis, LJ, Thuhan, A et al.. The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2.mdx mouse model of Duchenne muscular dystrophy. Am J Physiol Cell Physiol. 2024.326 (4)C1011-C1026 PMID:38145301
Miner, SES, McCarthy, MC, Ardern, CI, Perry, CGR, Toleva, O, Nield, LE et al.. The relationships between acetylcholine-induced chest pain, objective measures of coronary vascular function and symptom status. Front Cardiovasc Med. 2023.10 1217731 PMID:37719976
Bellissimo, CA, Castellani, LN, Finch, MS, Murugathasan, M, Gandhi, S, Sweeney, G et al.. Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688. Exp Physiol. 2023.108 (9)1108-1117 PMID:37415288
Garibotti, MC, Perry, CGR. Strength athletes and mitochondria: it's about 'time'. J Physiol. 2023.601 (14)2753-2754 PMID:37306149
Brown, JK, Perry, CGR, Prior, ET, Phillips, SM, Skelly, LE, Josse, AR et al.. Differential plasma branched-chain amino acid responses following the consumption of Greek-style yogurt and skimmed milk. Appl Physiol Nutr Metab. 2023.48 (7)544-549 PMID:36989535
Bellissimo, CA, Delfinis, LJ, Hughes, MC, Turnbull, PC, Gandhi, S, DiBenedetto, SN et al.. Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. Am J Physiol Cell Physiol. 2023.324 (5)C1141-C1157 PMID:36689672
Vainshtein, A, Slavin, MB, Cheng, AJ, Memme, JM, Oliveira, AN, Perry, CGR et al.. Scientific meeting report: International Biochemistry of Exercise 2022. J Appl Physiol (1985). 2022.133 (6)1381-1393 PMID:36356257
Delfinis, LJ, Bellissimo, CA, Gandhi, S, DiBenedetto, SN, Garibotti, MC, Thuhan, AK et al.. Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. JCI Insight. 2022.7 (24) PMID:36346680
Fuller, KNZ, McCoin, CS, Stierwalt, H, Allen, J, Gandhi, S, Perry, CGR et al.. Oral combined contraceptives induce liver mitochondrial reactive oxygen species and whole-body metabolic adaptations in female mice. J Physiol. 2022.600 (24)5215-5245 PMID:36326014
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