Farshad Babaeijandaghi
Biography
Dr. Babaeijandaghi received his MD from Tehran University of Medical Sciences before achieving his PhD in Experimental Medicine from the University of British Columbia. During his PhD, he worked under supervision of Dr. Fabio Rossi to study the role of stromal cells including resident macrophages and fibro-adipogenic progenitors in muscle regeneration and fibrosis. Currently, he is a scientist at Altos Labs in San Diego, California focusing on muscle aging and rejuvenation.
In 2023, Dr. Babaeijandaghi received the NMD4C early career award for publication of the year, for his study “Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics“.
Recent Publications
Babaeijandaghi, F, Kajabadi, N, Long, R, Tung, LW, Cheung, CW, Ritso, M et al.. DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages. Nat Commun. 2023.14 (1)8273 PMID:38092736
Kajabadi, N, Low, M, Jacques, E, Lad, H, Tung, LW, Babaeijandaghi, F et al.. Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss. Dev Cell. 2023.58 (6)489-505.e7 PMID:36898377
Babaeijandaghi, F, Paiero, A, Long, R, Tung, LW, Smith, SP, Cheng, R et al.. TNFα and IFNγ cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration. Proc Natl Acad Sci U S A. 2022.119 (44)e2209976119 PMID:36279473
Babaeijandaghi, F, Cheng, R, Kajabadi, N, Soliman, H, Chang, CK, Smandych, J et al.. Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics. Sci Transl Med. 2022.14 (651)eabg7504 PMID:35767650
Smaila, BD, Holland, SD, Babaeijandaghi, F, Henderson, HG, Rossi, FMV, Ramer, MS et al.. Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injury. Exp Neurol. 2020.334 113436 PMID:32814068
Pisconti, A, Banks, GB, Babaeijandaghi, F, Betta, ND, Rossi, FM, Chamberlain, JS et al.. Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration. Skelet Muscle. 2016.6 34 PMID:27757223
Lemos, DR, Babaeijandaghi, F, Low, M, Chang, CK, Lee, ST, Fiore, D et al.. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med. 2015.21 (7)786-94 PMID:26053624
Ahmadbeigi, N, Soleimani, M, Babaeijandaghi, F, Mortazavi, Y, Gheisari, Y, Vasei, M et al.. The aggregate nature of human mesenchymal stromal cells in native bone marrow. Cytotherapy. 2012.14 (8)917-24 PMID:22687188
Hallaji, Z, Babaeijandaghi, F, Akbarzadeh, M, Seyedi, SZ, Barzegari, M, Noormohammadpour, P et al.. A significant association exists between the severity of nail and skin involvement in psoriasis. J Am Acad Dermatol. 2012.66 (1)e12-3 PMID:22177647
Shabani, I, Haddadi-Asl, V, Soleimani, M, Seyedjafari, E, Babaeijandaghi, F, Ahmadbeigi, N et al.. Enhanced infiltration and biomineralization of stem cells on collagen-grafted three-dimensional nanofibers. Tissue Eng Part A. 2011.17 (9-10)1209-18 PMID:21143044
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