Matthew Triolo

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Postdoctoral Fellow

Khacho Lab, University of Ottawa


Research Interests: Skeletal muscle, muscle stem cells, aging, atrophy, mitochondrial biology, autophagy

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Biography

Dr. Matthew Triolo is a Postdoctoral Fellow working within Dr. Mireille Khacho’s lab in the Faculty of Medicine at the University of Ottawa. Matthew first completed his BSc in Kinesiology and Health Science with a Minor in Biology at York University. After completing his MSc investigating whether electrical pulse stimulation can enhance muscle cell activity under the guidance of Dr. Michael Connor, he subsequently worked towards his PhD as a member of the Muscle Health Research Centre at York University. While under the supervision of Dr. David Hood, his work focused on skeletal muscle autophagy, mitophagy and lysosome biogenesis in the context of aging, disuse, and exercise. As a new Postdoctoral Fellow, Dr. Triolo is investigating mechanisms by which mitochondria regulate muscle stem cell homeostasis and function. He enjoys playing a variety of sports including hockey, golf and baseball, and spending time with his family, friends, and cat, Luna. 

 

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Recent Publications

Vainshtein, A, Slavin, MB, Cheng, AJ, Memme, JM, Oliveira, AN, Perry, CGR et al.. Scientific Meeting report: International Biochemistry of Exercise 2022. J Appl Physiol (1985). 2022. PMID:36356257

Triolo, M, Bhattacharya, D, Hood, DA. Denervation induces mitochondrial decline and exacerbates lysosome dysfunction in middle-aged mice. Aging (Albany NY). 2022.14 PMID:36342767

Baker, N, Wade, S, Triolo, M, Girgis, J, Chwastek, D, Larrigan, S et al.. The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells. Cell Stem Cell. 2022.29 (9)1315-1332.e9 PMID:35998642

Triolo, M, Oliveira, AN, Kumari, R, Hood, DA. The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle. Skelet Muscle. 2022.12 (1)13 PMID:35690879

Triolo, M, Slavin, M, Moradi, N, Hood, DA. Time-dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation-induced disuse. J Physiol. 2022.600 (7)1683-1701 PMID:35067920

Triolo, M, Hood, DA. Manifestations of Age on Autophagy, Mitophagy and Lysosomes in Skeletal Muscle. Cells. 2021.10 (5) PMID:33946883

Triolo, M, Hood, DA. Mitochondrial breakdown in skeletal muscle and the emerging role of the lysosomes. Arch Biochem Biophys. 2019.661 66-73 PMID:30439362

Kim, Y, Triolo, M, Erlich, AT, Hood, DA. Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pflugers Arch. 2019.471 (3)431-440 PMID:30368578

Beyfuss, K, Erlich, AT, Triolo, M, Hood, DA. The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle. Sci Rep. 2018.8 (1)14710 PMID:30279494

Hood, DA, Memme, JM, Oliveira, AN, Triolo, M. Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging. Annu Rev Physiol. 2019.81 19-41 PMID:30216742

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