The Neuromuscular Disease Network for Canada

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Mireille Khacho

mireille khacho

Assistant Professor, Department of Biochemistry, Microbiology and Immunology, the University of Ottawa

Canada Research Chair tier2 in Mitochondrial Dynamics and Regenerative Medicine University of Ottawa | Neuromuscular disease center and the Ottawa Institute of Systems Biology (OISB) member

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Research Interests: Muscle stem cells, muscle regeneration, mitochondria, mitochondrial dynamics, metabolism, aging, neuromuscular diseases

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Biography

Dr. Khacho joined the Faculty of Medicine at the University of Ottawa as an Assistant Professor in the Department of Biochemistry, Microbiology and Immunology in January 2018. She is the Canada Research Chair tier2 in Mitochondrial Dynamics and Regenerative Medicine. She is also a member of the University of Ottawa Neuromuscular disease center and the Ottawa Institute of Systems Biology (OISB). Dr. Khacho has made significant contributions to our current understanding of the role of mitochondrial shape in stem cell function and longevity. Her work revealed the molecular mechanisms of how mitochondrial shape can direct the fate of stem cells and promote differentiation. As a postdoctoral fellow with Dr. Ruth Slack, a notable leader in neurobiology, Dr. Khacho made the pioneering discovery that mitochondria are upstream signaling centers that dictate stem cell fate. This work has far reaching implications in aging and regenerative medicine and has now established a new area of research that bridges mitochondrial/metabolic regulation with aging and degenerative disease and stem cell function. Dr. Khacho’s research is focused on understanding key mitochondrial signaling pathways that are crucial for stem cell maintenance during aging and degenerative diseases. The discovery and characterization of these pathways would pave the way towards advancing stem cell therapies.

Recent publications

Thumiah-Mootoo, M, Podinic, T, Khacho, M. Assessment of Mitochondrial Reactive Oxygen Species and Redox Regulation in Stem Cells. Methods Mol Biol. 2021.2277 289-297 PMID:34080158

Cairns, G, Thumiah-Mootoo, M, Burelle, Y, Khacho, M. Mitophagy: A New Player in Stem Cell Biology. Biology (Basel). 2020.9 (12) PMID:33352783

Bondy-Chorney, E, Abramchuk, I, Nasser, R, Holinier, C, Denoncourt, A, Baijal, K et al.. A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells. Cell Rep. 2020.33 (4)108318 PMID:33113373

Anilkumar, U, Khacho, M, Cuillerier, A, Harris, R, Patten, DA, Bilen, M et al.. MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions. Cell Death Dis. 2020.11 (5)321 PMID:32371858

Baker, N, Patel, J, Khacho, M. Linking mitochondrial dynamics, cristae remodeling and supercomplex formation: How mitochondrial structure can regulate bioenergetics. Mitochondrion. 2019.49 259-268 PMID:31207408

Khacho, M, Harris, R, Slack, RS. Mitochondria as central regulators of neural stem cell fate and cognitive function. Nat Rev Neurosci. 2019.20 (1)34-48 PMID:30464208

Khacho, M, Slack, RS. Mitochondrial activity in the regulation of stem cell self-renewal and differentiation. Curr Opin Cell Biol. 2017.49 1-8 PMID:29175320

Khacho, M, Slack, RS. Mitochondrial and Reactive Oxygen Species Signaling Coordinate Stem Cell Fate Decisions and Life Long Maintenance. Antioxid Redox Signal. 2018.28 (11)1090-1101 PMID:28657337

Khacho, M, Slack, RS. Mitochondrial dynamics in the regulation of neurogenesis: From development to the adult brain. Dev Dyn. 2018.247 (1)47-53 PMID:28643345

Khacho, M, Clark, A, Svoboda, DS, MacLaurin, JG, Lagace, DC, Park, DS et al.. Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Hum Mol Genet. 2017.26 (17)3327-3341 PMID:28595361

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