Myogenesis Discussion Group: A seminar series on skeletal, cardiac and smooth muscle research held on the last Monday of each month.

Speaker

Dr. Steve Guzman | Aguilar Lab at the University of Michigan.

Details: Dr. Steve Guzman is a postdoctoral fellow in the Aguilar Lab at the University of Michigan. His work focuses on how RNA processing and nuclear organization regulate muscle stem cell function during regeneration and aging. In particular, he uses paired single-cell short- and long-read RNA sequencing, ARTR-Seq, an RNA proximity labeling and sequencing assay, super-resolution imaging, and computational isoform analysis to understand how nuclear speckles shape splicing, isoform choice, and regenerative capacity in muscle stem cells. His recent work investigates how nuclear speckles expand during muscle stem cell activation, how their disruption impairs regeneration, and how aging remodels nuclear speckle- associated RNA programs and isoform usage, contributing to defective muscle repair.

Title: Nuclear Speckles Regulate Splicing During Muscle Stem Cell Activation and Aging
Date: Monday, 25 May 2026
Time: 2-3pm EST

To register please email the event organizers, mathew and bella

Learn more at https://mbd.ccrm.ca/research/discussion-groups/, and follow Myogenesis Discussion Group on Twitter @MyogenesisGroup