Léa Lescouzères
Biography
Dr. Lescouzères completed her PhD in Neurosciences (2017-2022) in Dr. Pascale Bomont’s lab at University Lyon 1 (NeuroMyoGene Institute, Lyon, France). In 2022, she joined Dr. Kessen Patten’s lab as a postdoctoral research fellow at the INRS-Institut Armand Frappier in Canada. She is currently working on zebrafish models of amyotrophic lateral sclerosis (ALS) with the aim of identifying new physiopathological mechanisms induced by mutations in the C9ORF72 gene, and new therapeutic targets.
Recent Publications
Lescouzères, L, Hassen-Khodja, C, Baudot, A, Bordignon, B, Bomont, P. A multilevel screening pipeline in zebrafish identifies therapeutic drugs for GAN. EMBO Mol Med. 2023.15 (7)e16267 PMID:37144692
Lescouzères, L, Bordignon, B, Bomont, P. Development of a high-throughput tailored imaging method in zebrafish to understand and treat neuromuscular diseases. Front Mol Neurosci. 2022.15 956582 PMID:36204134
Lescouzères, L, Bomont, P. E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy. Front Physiol. 2020.11 1022 PMID:33192535
Cousineau, J, Lescouzères, L, Taupignon, A, Delgado-Zabalza, L, Valjent, E, Baufreton, J et al.. Dopamine D2-Like Receptors Modulate Intrinsic Properties and Synaptic Transmission of Parvalbumin Interneurons in the Mouse Primary Motor Cortex. eNeuro. 2020.7 (3) PMID:32321772
Arribat, Y, Mysiak, KS, Lescouzères, L, Boizot, A, Ruiz, M, Rossel, M et al.. Sonic Hedgehog repression underlies gigaxonin mutation-induced motor deficits in giant axonal neuropathy. J Clin Invest. 2019.129 (12)5312-5326 PMID:31503551
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