The Neuromuscular Disease Network for Canada

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Mo Zhao

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NMD4C

Postdoctoral Research Fellow, Genetics & Genomic Biology at the Hospital for Sick Children, Toronto


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Research Interests: muscle disorders, disease models, zebrafish, microscopy, drug discovery

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Biography

Dr. Mo Zhao completed her PhD in Molecular Genetics (2013-2017) in Dr. Robert Bryson-Richardson’s lab at Monash University (Melbourne, Australia). Her PhD project involved the use of zebrafish and high-resolution microscopic techniques to study sarcomeric M-bands. In 2017, she joined Dr. James Dowling’s lab as a postdoctoral research fellow in the Department of Genetics & Genomic Biology at the Hospital for Sick Children in Toronto, Canada. She is currently working on zebrafish models of centronuclear myopathy with the aim of identifying therapeutic targets for pre/clinical trials.

Read Dr. Zhao’s blog here!

Recent publications

Zhao, M, Smith, L, Volpatti, J, Fabian, L, Dowling, JJ. Insights into wild-type dynamin 2 and the consequences of DNM2 mutations from transgenic zebrafish. Hum Mol Genet. 2019.28 (24)4186-4196 PMID:31691805

Zhao, M, Maani, N, Dowling, JJ. Dynamin 2 (DNM2) as Cause of, and Modifier for, Human Neuromuscular Disease. Neurotherapeutics. 2018.15 (4)966-975 PMID:30426359

Sztal, TE, Zhao, M, Williams, C, Oorschot, V, Parslow, AC, Giousoh, A et al.. Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathol. 2015.130 (3)389-406 PMID:25931053

Ruparelia, AA, Zhao, M, Currie, PD, Bryson-Richardson, RJ. Characterization and investigation of zebrafish models of filamin-related myofibrillar myopathy. Hum Mol Genet. 2012.21 (18)4073-83 PMID:22706277

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