CIHR-IMHA Dialogue Series
CIHR-IMHA Dialogue Series
Myogenesis Discussion Group | Extracellular Vesicle–Based Modulation of Atrial Remodeling in Atrial Fibrillation
CIHR-IMHA Dialogue Series
World Muscle Society: Myology Café – 30 April 2026
Myogenesis Discussion Group | Extracellular Vesicle–Based Modulation of Atrial Remodeling in Atrial Fibrillation
Myogenesis Discussion Group: A seminar series on skeletal, cardiac and smooth muscle research held on the last Monday of each month.
Speaker
Dr. Darryl Davis | Cardiac Electrophysiologist and Scientist, University of Ottawa Heart Institute & Professor, University of Ottawa
(Click to view/Close the speaker’s bio)
Dr. Darryl Davis is a cardiac electrophysiologist and clinician-scientist at the University of Ottawa Heart Institute. He leads translational research on the mechanisms underlying atrial fibrillation and the development of novel biologic therapies. His work integrates human cell systems, animal models, and clinically relevant approaches to understand how structural and inflammatory remodeling contribute to arrhythmogenesis.
Dr. Davis’s research has advanced the study of extracellular vesicles (EVs) as mediators of intercellular signaling in the heart. His group has developed cardiac-derived EV platforms to investigate how paracrine signaling influences fibroblast activation, immune responses, and tissue-level electrophysiological properties in the atria
Details
In this seminar, Dr. Davis will present recent work examining atrial fibrillation as a form of acquired cardiomyopathy driven by inflammation and fibrosis. He will discuss how EVs modulate key pathways involved in this process, including suppression of the NLRP3 inflammasome and attenuation of profibrotic signaling. Using human cell models and in vivo systems, he will highlight how targeting the atrial substrate can alter arrhythmia susceptibility and promote functional recovery. The talk will emphasize the relationship between structural remodeling and electrophysiological dysfunction, with implications for developing mechanism-based therapies for atrial fibrillation.
Title: Extracellular Vesicle–Based Modulation of Atrial Remodeling in Atrial Fibrillation
Date: Monday, 27 April 2026
Time: 2-3pm EST
To register please email the event organizers, mathew and bella
Learn more at https://mbd.ccrm.ca/research/discussion-groups/, and follow Myogenesis Discussion Group on Twitter @MyogenesisGroup